Armstrong April W, Mburu Sicily, Gondo George C, Kornyeyeva Elena, Frade Susan, Ogdie Alexis
Department of Dermatology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA, 90095, USA.
International Federation of Psoriasis Associations, Stockholm, Sweden.
Drugs Real World Outcomes. 2025 Aug 29. doi: 10.1007/s40801-025-00499-6.
Psoriatic disease (PsD) is a chronic, multisystem, inflammatory disorder encompassing psoriasis, psoriatic arthritis (PsA), and their associated comorbidities.
The aim of this subanalysis of the global "Psoriasis and Beyond" study was to evaluate patients' experiences of living with PsD in the USA.
The study included a cross-sectional, quantitative, 25-min online survey of adults with self-reported, healthcare professional-diagnosed, moderate-to-severe psoriasis, with or without PsA. USA-based patients were recruited through online panels by the Institut de Publique Sondage D'Opinion Secteur and The National Psoriasis Foundation.
This analysis included 793 US patients with psoriasis; 43% also had PsA. Overall, 75% of patients knew that their disease was systemic, and 65% had heard the term "psoriatic disease." Of patients without diagnosed PsA, 50% screened positive for PsA using the Psoriasis Epidemiology Screening Tool. Psoriasis negatively affected emotional well-being and quality of life (QoL) in the majority of patients (87% and 91%, respectively). Overall, 29% of patients reported that they could not work or study in the week prior to the survey; of these, 98% responded that psoriasis had a very or extremely large impact on their QoL. Mean diagnostic delays of 3.7 and 3.3 years for psoriasis and PsA, respectively, were reported.
This analysis of USA-based patients with PsD highlights the profound impact of PsD on emotional well-being and QoL and suggests potential underdiagnosis of PsA. There is a need to ensure early PsD diagnosis and to provide holistic treatment, including mental health support.
银屑病性疾病（PsD）是一种慢性、多系统炎症性疾病，包括银屑病、银屑病关节炎（PsA）及其相关合并症。
这项全球“银屑病及其他”研究的子分析旨在评估美国患者患PsD的生活体验。
该研究包括一项横断面、定量的25分钟在线调查，对象为自我报告、经医疗专业人员诊断为中度至重度银屑病、伴有或不伴有PsA的成年人。美国患者由公共舆论调查研究所和国家银屑病基金会通过在线小组招募。
该分析纳入了793名美国银屑病患者；43%的患者还患有PsA。总体而言，75%的患者知道他们的疾病是全身性的，65%的患者听说过“银屑病性疾病”这个术语。在未诊断出PsA的患者中，50%使用银屑病流行病学筛查工具筛查出PsA呈阳性。银屑病对大多数患者的情绪健康和生活质量（QoL）产生了负面影响（分别为87%和91%）。总体而言，29%的患者报告称在调查前一周无法工作或学习；其中98%的患者表示银屑病对他们的生活质量有非常大或极其大的影响。据报告，银屑病和PsA的平均诊断延迟分别为3.7年和3.3年。
这项对美国PsD患者的分析突出了PsD对情绪健康和生活质量的深远影响，并表明PsA可能存在诊断不足的情况。需要确保早期诊断PsD并提供全面治疗，包括心理健康支持。
