Kim Hyeon-Ki, Shibata Shigenobu
National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Graduate School of Medicine, Tohoku University, Sendai, Japan.
Adv Exp Med Biol. 2025;1478:101-112. doi: 10.1007/978-3-031-88361-3_6.
Since the discovery of clock gene in mammals, the physiological role of the internal clock, which produces a rhythm of approximately 24 h per day, has been revealed, and it has become clear that a regular life rhythm is important for maintaining good health. Skeletal muscle function is no exception, and has been reported to be regulated by the internal clock. In the skeletal muscle, more than 2300 genes exhibit circadian rhythms and are involved in a wide range of functions, including myogenesis, transcription, and metabolism. In this chapter, we discuss the effects of exercise on the regulation of the skeletal muscle internal clock and its potential timing effects, starting from the regulation of skeletal muscle function by the internal clock.
自从在哺乳动物中发现生物钟基因以来，产生大约每天24小时节律的内在生物钟的生理作用已被揭示，并且已经明确规律的生活节奏对于保持健康很重要。骨骼肌功能也不例外，据报道它受内在生物钟的调节。在骨骼肌中，超过2300个基因表现出昼夜节律，并参与包括肌发生、转录和代谢在内的广泛功能。在本章中，我们从内在生物钟对骨骼肌功能的调节开始，讨论运动对骨骼肌内在生物钟调节的影响及其潜在的时间效应。
