Bzour Aseel, Alzoubi Qasem, Sarhan Nasem, Kh Ibrahimi Ahmad, Obeidat Mouness, Musharbash Awni, Al-Hussaini Maysa, Maraqa Bayan, Amayiri Nisreen
Department of Pediatrics, King Hussein Cancer Center, Amman, Jordan.
Department of Diagnostic Radiology, King Hussein Cancer Center, Amman, Jordan.
Pediatr Blood Cancer. 2025 Nov;72(11):e31989. doi: 10.1002/pbc.31989. Epub 2025 Aug 13.
Medulloblastoma, the most prevalent malignant brain tumor in children, typically requires a multimodal treatment approach including surgery, chemotherapy, and craniospinal radiation. Chemotherapy is particularly crucial in controlling tumor growth in young children (<3-5 years old), where craniospinal radiation is often avoided due to its detrimental neurocognitive side effects. This report highlights two remarkable young children with metastatic SHH-medulloblastoma who presented with severe and life-threatening neurological symptoms. Following emergency administration of intensive chemotherapy, both patients demonstrated rapid and significant clinical and radiological response, underscoring the potential use of chemotherapy as a salvage therapy in such critical situations.
髓母细胞瘤是儿童中最常见的恶性脑肿瘤，通常需要采用多模式治疗方法，包括手术、化疗和全脑全脊髓放疗。化疗对于控制幼儿（<3 - 5岁）的肿瘤生长尤为关键，因为全脑全脊髓放疗因其有害的神经认知副作用，在幼儿中常被避免使用。本报告重点介绍了两名患有转移性SHH型髓母细胞瘤的幼儿，他们出现了严重且危及生命的神经症状。在紧急给予强化化疗后，两名患者均表现出快速且显著的临床和影像学反应，突显了化疗在此类危急情况下作为挽救治疗的潜在用途。
