Meng XiangTian, Zhou Hongyan
China-Japan Union Hospital, Jilin University, Changchun, China.
Front Med (Lausanne). 2025 Aug 13;12:1633155. doi: 10.3389/fmed.2025.1633155. eCollection 2025.
The aim of this study is to explore the correlation between grade and total number of nasal and temporal side lid-parallel conjunctival folds (LIPCOFs) for signs and dry eye severity grading of different types of dry eye disease.
The data of 76 eyes of 38 patients with dry eye disease were selected. Fluorescein Breakup Time (FBUT), tear secretion function, corneal staining test, and slit lamp examination were performed. The above results, including the grade and the total number of nasal and temporal side LIPCOFs, were recorded. The causal relationship between parametric variables was analyzed by Pearson's correlation, and the causal relationship between non-parametric variables was analyzed by Spearman's correlation. Paired -test was used to analyze statistical differences between different groups. Benjamini-Hochberg False Discovery Rate (BH-FDR) correction is used to reduce the risk of type I error rate inflation when there is a correlation between multiple indicators.
A significant negative correlation was found between the grade of temporal side LIPCOF and the FBUT in all 76 eyes, both in the aqueous deficiency group and the non-aqueous deficiency group. Similarly, temporal side LIPCOF showed a reliable positive correlation with dry eye disease severity grading in the non-aqueous deficiency group. However, this correlation was not statistically significant in the aqueous deficiency group. For the grade of nasal side LIPCOF, there was no statistical correlation between the conjunctival fold grade and the FBUT in all 76 eyes. However, there was a significant positive correlation between the conjunctival fold grade and the FBUT in the aqueous deficiency group. In the non-aqueous deficiency group, there was a significant negative correlation between the conjunctival fold grade and FBUT. For the total number of LIPCOFs, there was no statistical correlation between the total number of LIPCOFs and FBUT in all 76 eyes and the aqueous deficiency group. However, there was a significant negative correlation between the total number of LIPCOFs and FBUT in the non-aqueous deficiency group.
本研究旨在探讨不同类型干眼疾病体征和干眼严重程度分级中鼻侧和颞侧睑裂平行结膜皱襞（LIPCOFs）的分级与总数之间的相关性。
选取38例干眼患者的76只眼的数据。进行荧光素泪膜破裂时间（FBUT）、泪液分泌功能、角膜染色试验和裂隙灯检查。记录上述结果，包括分级以及鼻侧和颞侧LIPCOFs的总数。参数变量之间的因果关系采用Pearson相关性分析，非参数变量之间的因果关系采用Spearman相关性分析。采用配对t检验分析不同组之间的统计学差异。当多个指标之间存在相关性时，使用Benjamini-Hochberg错误发现率（BH-FDR）校正来降低I型错误率膨胀的风险。
在所有76只眼中，无论是水液缺乏组还是非水液缺乏组，颞侧LIPCOF分级与FBUT之间均存在显著负相关。同样，在非水液缺乏组中，颞侧LIPCOF与干眼疾病严重程度分级呈可靠的正相关。然而，在水液缺乏组中，这种相关性无统计学意义。对于鼻侧LIPCOF分级，在所有76只眼中，结膜皱襞分级与FBUT之间无统计学相关性。然而，在水液缺乏组中，结膜皱襞分级与FBUT之间存在显著正相关。在非水液缺乏组中，结膜皱襞分级与FBUT之间存在显著负相关。对于LIPCOFs总数，在所有76只眼和水液缺乏组中，LIPCOFs总数与FBUT之间无统计学相关性。然而，在非水液缺乏组中，LIPCOFs总数与FBUT之间存在显著负相关。
