Xu Pan, Ling Shan-Shan, Hu E, Yi Bi-Xia
Department of Gynecology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua 321000, Zhejiang Province, China.
Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China.
World J Clin Cases. 2025 Sep 26;13(27):107158. doi: 10.12998/wjcc.v13.i27.107158.
Primary signet ring cell carcinoma of the urethra in women is an exceedingly rare malignancy. It was first reported in postmenopausal women in 1987, and only five patients have been reported to date.
A 61-year-old woman presented with irregular vaginal bleeding, and subsequent evaluation identified a tumor located in the distal urethra. Upon diagnosis of primary urethral carcinoma, she underwent a distal urethrectomy. Histopathological analysis demonstrated that the tumor consisted of a combination of intestinal adenocarcinoma and signet ring cell carcinoma. At the 12-month postoperative follow-up, there was no evidence of disease recurrence.
This case report highlights the exceptional rarity of female urethral signet ring cell carcinoma, emphasizing the importance of early clinical detection and the necessity for precise and conservative surgical intervention.
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