Xu Pan, Ling Shan-Shan, Hu E, Yi Bi-Xia
Department of Gynecology, Affiliated Jinhua Hospital of Wenzhou Medical University, Jinhua 321000, Zhejiang Province, China.
Zhejiang University School of Medicine, Hangzhou 310006, Zhejiang Province, China.
World J Clin Cases. 2025 Sep 26;13(27):107158. doi: 10.12998/wjcc.v13.i27.107158.
Primary signet ring cell carcinoma of the urethra in women is an exceedingly rare malignancy. It was first reported in postmenopausal women in 1987, and only five patients have been reported to date.
A 61-year-old woman presented with irregular vaginal bleeding, and subsequent evaluation identified a tumor located in the distal urethra. Upon diagnosis of primary urethral carcinoma, she underwent a distal urethrectomy. Histopathological analysis demonstrated that the tumor consisted of a combination of intestinal adenocarcinoma and signet ring cell carcinoma. At the 12-month postoperative follow-up, there was no evidence of disease recurrence.
This case report highlights the exceptional rarity of female urethral signet ring cell carcinoma, emphasizing the importance of early clinical detection and the necessity for precise and conservative surgical intervention.
女性原发性尿道印戒细胞癌是一种极其罕见的恶性肿瘤。1987年首次报道于绝经后女性，迄今为止仅报道了5例患者。
一名61岁女性出现不规则阴道出血，随后的评估发现远端尿道有一个肿瘤。诊断为原发性尿道癌后，她接受了远端尿道切除术。组织病理学分析表明，肿瘤由肠腺癌和印戒细胞癌组成。术后12个月随访时，没有疾病复发的证据。
本病例报告突出了女性尿道印戒细胞癌的异常罕见性，强调了早期临床检测的重要性以及精确和保守手术干预的必要性。
