Joseph Danny Darlington Carbin, Chinnathambi Jagatheswaran, Jamburaj Arunkumar
Department of Urology, Pondicherry Institute of Medical Sciences, Pondicherry, India.
Ecancermedicalscience. 2022 Jul 7;16:1426. doi: 10.3332/ecancer.2022.1426. eCollection 2022.
Malignant tumours of the male urethra are rare and commonly present at an advanced stage. The most common type of urethral cancer is urothelial carcinoma, followed by squamous cell carcinoma. Less than 5% of urethral cancers are adenocarcinoma. We report a young male with signet ring cell carcinoma of the membranous urethra who presented with recurrent lower urinary tract symptoms. Although he was initially treated for a urinary tract infection, the correct diagnosis was made with an appropriate imaging workup. He underwent radical urethrectomy with total pelvic exenteration with bilateral extended pelvic lymph node dissection. Ileal conduit and colostomy were performed as urinary and bowel diversions, respectively. The patient received adjuvant chemotherapy, however, succumbed to COVID-19 8 months after the procedure. This case has been presented to highlight the high index of suspicion required to diagnose this rare malignancy.
男性尿道恶性肿瘤较为罕见，通常在晚期出现。最常见的尿道癌类型是尿路上皮癌，其次是鳞状细胞癌。尿道癌中腺癌占比不到5%。我们报告了一名患有膜部尿道印戒细胞癌的年轻男性，他表现为反复出现的下尿路症状。尽管最初他被当作尿路感染进行治疗，但通过适当的影像学检查才做出了正确诊断。他接受了根治性尿道切除术、全盆腔脏器清除术以及双侧扩大盆腔淋巴结清扫术。分别进行了回肠代膀胱术和结肠造口术作为尿路和肠道改道。患者接受了辅助化疗，但在手术后8个月死于新冠病毒感染。本病例旨在强调诊断这种罕见恶性肿瘤所需的高度怀疑指数。
