Xue Xiayan, Zhang Sicong, Guo Qingjuan, Wu Jiali, Zhang Jingjing, Wang Cong, Shan Chunlei
Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Hum Neurosci. 2025 Aug 13;19:1603797. doi: 10.3389/fnhum.2025.1603797. eCollection 2025.
Post-stroke cognitive impairment (PSCI) significantly hinders functional recovery and quality of life in stroke survivors. Although transcranial direct current stimulation (tDCS) has emerged as a promising non-invasive neuromodulation technique to improve cognitive function, conventional single-target tDCS approaches often yield inconsistent outcomes across cognitive domains.
This randomized controlled trial aims to investigate the efficacy and underlying neural mechanisms of dual-target anodal tDCS (a-tDCS) in individuals with PSCI. Sixty participants will be randomly assigned to either a dual-target stimulation group or a single-target stimulation group. Each group will receive 10 sessions of tDCS over two weeks. Cognitive performance will be assessed using the Montreal Cognitive Assessment (MoCA) as the primary outcome, while secondary outcomes include the digit span test, Trail Making Test, and modified Barthel Index. Functional near-infrared spectroscopy (fNIRS) will be used to assess cortical activation and functional connectivity before and after the intervention.
The findings are expected to provide evidence on the efficacy and underlying mechanisms of dual-target tDCS in PSCI rehabilitation, potentially offering a more effective neuromodulatory intervention strategy for cognitive recovery in stroke survivors.
http://www.chictr.org.cn, identifier ChiCTR2500096896.
中风后认知障碍（PSCI）严重阻碍中风幸存者的功能恢复和生活质量。尽管经颅直流电刺激（tDCS）已成为一种有前景的非侵入性神经调节技术，可改善认知功能，但传统的单靶点tDCS方法在不同认知领域的效果往往不一致。
本随机对照试验旨在研究双靶点阳极tDCS（a-tDCS）对PSCI患者的疗效及潜在神经机制。60名参与者将被随机分为双靶点刺激组或单靶点刺激组。每组将在两周内接受10次tDCS治疗。认知表现将以蒙特利尔认知评估量表（MoCA）作为主要指标进行评估，次要指标包括数字广度测试、连线测验和改良巴氏指数。功能近红外光谱技术（fNIRS）将用于评估干预前后的皮质激活和功能连接。
研究结果有望为双靶点tDCS在PSCI康复中的疗效及潜在机制提供证据，可能为中风幸存者的认知恢复提供更有效的神经调节干预策略。
