Wade A E, Evans J S
Pharmacology. 1977;15(4):289-301. doi: 10.1159/000136702.
Ingestion of high levels of thiamin significantly decreased the activity of cytochrome P-450, NADPH cytochrome c reductase, and the metabolism of aniline and ethylmorphine. Apparent VmaxS for ethylmorphine N-demethylase and aniline hydroxylase were decreased by high levels of riboflavin even though NADPH cytochrome c reductase was elevated. High levels of dietary pyridoxine significantly decreased only the Vmax for aniline hydroxylase. Generally, norethindrone produces either no change or slight depression of cytochrome P-450 regardless or diet, whereas the administration of norethindrone produced no change or an increase in activity of c reductase and ethylmorphine N-demethylase. Norethindrone induces aniline hydroxylase in animals fed all diets except those deficient in thiamin and riboflavin. The activities of the four parameters of the drug metabolizing system measured in these studies as well as the effects of norethindrone are clearly affected by the dietary status of the animal.
摄入高水平硫胺素会显著降低细胞色素P - 450、NADPH细胞色素c还原酶的活性以及苯胺和乙基吗啡的代谢。即使NADPH细胞色素c还原酶活性升高，高水平核黄素也会降低乙基吗啡N - 脱甲基酶和苯胺羟化酶的表观Vmax。高水平的膳食吡哆醇仅显著降低苯胺羟化酶的Vmax。一般来说，无论饮食如何，炔诺酮对细胞色素P - 450要么没有影响，要么使其略有降低，而炔诺酮的给药对c还原酶和乙基吗啡N - 脱甲基酶的活性没有影响或使其增加。炔诺酮在除硫胺素和核黄素缺乏的所有饮食喂养的动物中诱导苯胺羟化酶。在这些研究中测量的药物代谢系统的四个参数的活性以及炔诺酮的作用明显受到动物饮食状况的影响。
