Yan Kurlya, Dharia Ashni, Lygouris Georgios
Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
Department of Internal Medicine, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
JACC Case Rep. 2025 Aug 27;30(25):104880. doi: 10.1016/j.jaccas.2025.104880.
Carney complex (CNC) is a rare genetic disorder characterized by endocrine and nonendocrine tumors, including cardiac myxomas, which are a leading cause of mortality due to embolic events, arrhythmias, heart failure, and sudden cardiac death.
We present the case of a 33-year-old man with CNC who experienced stroke-like symptoms due to recurrence of a left atrial myxoma 10 years after initial resection. He underwent successful surgical resection.
Cardiac myxoma recurrence is higher in patients with CNC, with rates up to 22% compared with 2% to 3% in sporadic cases. This case underscores the importance of lifelong, multidisciplinary care and rigorous surveillance to prevent severe cardiovascular complications.
TAKE-HOME MESSAGES: Although rare, it is important to recognize the clinical features and complications of CNC, including the increased risk of recurrent cardiac myxomas. Lifelong cardiac imaging is recommended at 6- to 12-month intervals in patients with CNC.
卡尼综合征（CNC）是一种罕见的遗传性疾病，其特征为内分泌和非内分泌肿瘤，包括心脏黏液瘤，心脏黏液瘤是因栓塞事件、心律失常、心力衰竭和心源性猝死导致死亡的主要原因。
我们报告一例33岁患有CNC的男性患者，在初次切除左心房黏液瘤10年后，因黏液瘤复发出现类似中风的症状。他接受了成功的手术切除。
CNC患者心脏黏液瘤的复发率更高，高达22%，而散发性病例的复发率为2%至3%。该病例强调了终身多学科护理和严格监测以预防严重心血管并发症的重要性。
尽管罕见，但认识CNC的临床特征和并发症很重要，包括心脏黏液瘤复发风险增加。建议对CNC患者每6至12个月进行一次终身心脏成像检查。
Zotero 插件
