共价化学探针
Covalent chemical probes.
作者信息
Backus Keriann M, Wilson Andrew J
机构信息
Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
Department of Chemistry and Biochemistry, UCLA, Los Angeles, CA, USA.
出版信息
Commun Chem. 2025 Aug 29;8(1):266. doi: 10.1038/s42004-025-01652-6.
Abstract
is pleased to introduce a Collection of research works focused on recent developments within the interdisciplinary field of Covalent chemical probes. Here, the Guest Editors highlight key themes and look towards the future of this research field.
摘要
很高兴推出一系列聚焦于共价化学探针跨学科领域近期进展的研究著作。在此，客座编辑们强调了关键主题，并展望了这一研究领域的未来。
相似文献
1
Covalent chemical probes.共价化学探针
Commun Chem. 2025 Aug 29;8(1):266. doi: 10.1038/s42004-025-01652-6.
2
Covalent Probes for Carbohydrate-Active Enzymes: From Glycosidases to Glycosyltransferases.用于碳水化合物活性酶的共价探针：从糖苷酶到糖基转移酶
Methods Enzymol. 2018;598:237-265. doi: 10.1016/bs.mie.2017.06.016. Epub 2017 Oct 31.
3
Rapid, potent, and persistent covalent chemical probes to deconvolute PI3Kα signaling.用于解析PI3Kα信号传导的快速、强效且持久的共价化学探针。
Chem Sci. 2024 Nov 12;15(48):20274-20291. doi: 10.1039/d4sc05459h. eCollection 2024 Dec 11.
4
Chemical Probes for the Adenosine Receptors.腺苷受体的化学探针
Pharmaceuticals (Basel). 2019 Nov 12;12(4):168. doi: 10.3390/ph12040168.
5
Covalent Modification of Protein by Chemical Probe in Living Cells for Structural and Interaction Studies.用于结构和相互作用研究的活细胞中化学探针介导的蛋白质共价修饰
Chembiochem. 2025 Jan 2;26(1):e202400715. doi: 10.1002/cbic.202400715. Epub 2024 Nov 11.
6
Covalent docking of large libraries for the discovery of chemical probes.利用共价对接技术对大型文库进行筛选，以发现化学探针。
Nat Chem Biol. 2014 Dec;10(12):1066-72. doi: 10.1038/nchembio.1666. Epub 2014 Oct 26.
7
Affinity-based covalent sialyltransferase probes enabled by ligand-directed chemistry.基于亲和力的共价唾液酸转移酶探针，由配体导向化学实现。
Chem Sci. 2025 Jan 13;16(7):3336-3344. doi: 10.1039/d4sc07184k. eCollection 2025 Feb 12.
8
Opportunities and challenges for the development of covalent chemical immunomodulators.共价化学免疫调节剂发展的机遇与挑战。
Bioorg Med Chem. 2019 Aug 1;27(15):3421-3439. doi: 10.1016/j.bmc.2019.05.050. Epub 2019 Jun 5.
9
Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging.基于共价组装策略的小分子荧光探针用于化学选择性生物成像。
RSC Adv. 2022 Jan 7;12(3):1393-1415. doi: 10.1039/d1ra08037g. eCollection 2022 Jan 5.
10
"Covalent-Disassembly"-Based Approaches For Sensing Applications.基于共价拆卸的传感应用方法
Chemistry. 2024 Apr 5;30(20):e202302705. doi: 10.1002/chem.202302705. Epub 2024 Jan 26.
本文引用的文献
1
Structure-based rational design of covalent probes.基于结构的共价探针合理设计。
Commun Chem. 2025 Aug 12;8(1):242. doi: 10.1038/s42004-025-01606-y.
2
Chemoproteomics identifies protein ligands for monoacylglycerol lipids.化学蛋白质组学鉴定单酰甘油脂质的蛋白质配体。
Commun Chem. 2025 Jul 4;8(1):197. doi: 10.1038/s42004-025-01589-w.
3
Structure-based design of potent and selective inhibitors of the HECT ligase NEDD4.基于结构的HECT连接酶NEDD4强效和选择性抑制剂的设计
Commun Chem. 2025 May 28;8(1):164. doi: 10.1038/s42004-025-01557-4.
4
A modular click ligand-directed approach to label endogenous dopamine D receptors in live cells.一种用于在活细胞中标记内源性多巴胺 D 受体的模块化点击配体导向方法。
Commun Chem. 2025 Apr 11;8(1):113. doi: 10.1038/s42004-025-01504-3.
5
Factors affecting irreversible inhibition of EGFR and influence of chirality on covalent binding.影响表皮生长因子受体不可逆抑制的因素及手性对共价结合的影响。
Commun Chem. 2025 Apr 9;8(1):111. doi: 10.1038/s42004-025-01501-6.
6
Development of potential immunomodulatory ligands targeting natural killer T cells inspired by gut symbiont-derived glycolipids.受肠道共生菌衍生糖脂启发开发靶向自然杀伤T细胞的潜在免疫调节配体。
Commun Chem. 2025 Apr 1;8(1):98. doi: 10.1038/s42004-025-01497-z.
7
Proteome selectivity profiling of photoaffinity probes derived from imidazopyrazine-kinase inhibitors.源自咪唑并吡嗪激酶抑制剂的光亲和探针的蛋白质组选择性分析
Commun Chem. 2025 Feb 6;8(1):34. doi: 10.1038/s42004-025-01436-y.
8
Chemical- and photo-activation of protein-protein thiol-ene coupling for protein profiling.用于蛋白质分析的蛋白质-蛋白质硫醇-烯偶联的化学和光活化
Commun Chem. 2025 Jan 29;8(1):25. doi: 10.1038/s42004-025-01412-6.
9
Enantioselective OTUD7B fragment discovery through chemoproteomics screening and high-throughput optimisation.通过化学蛋白质组学筛选和高通量优化实现对映选择性OTUD7B片段的发现
Commun Chem. 2025 Jan 15;8(1):12. doi: 10.1038/s42004-025-01410-8.
10
Ortho-functionalized pyridinyl-tetrazines break the inverse correlation between click reactivity and cleavage yields in click-to-release chemistry.邻位官能化吡啶基四嗪打破了点击释放化学中点击反应性与裂解产率之间的反相关关系。
Commun Chem. 2024 Dec 19;7(1):302. doi: 10.1038/s42004-024-01392-z.
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