Kahraman Nazlı Hilal, Tunç Serap Keskin
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Van Yuzuncu Yil University, Van, Türkiye.
Department of Oral and Maxillofacial Surgery, Hamidiye Faculty of Dentistry, University of Medical Sciences, İstanbul, Türkiye.
BMC Oral Health. 2025 Aug 29;25(1):1383. doi: 10.1186/s12903-025-06729-1.
Temporomandibular joint disorders are significant health issues characterized by dysfunctions in the masticatory muscles and the temporomandibular joint. These disorders are often associated with stress, oral parafunctions, and habits such as bruxism. Treating bruxism and other parafunctional habits can reduce symptoms of myofascial pain. While the etiology of bruxism remains unclear, psychological factors like stress and anxiety, along with central nervous system, are thought that it will provoke. Additionally, a significant relationship has been reported between low serum vitamin D levels and bruxism. The aim of this study is to comparatively evaluate the effectiveness of nonsteroidal anti-inflammatory drug treatment and vitamin D supplementation on symptoms in individuals with myofascial pain and vitamin D deficiency.
This study included patients aged 18-40, diagnosed with myofascial pain (MP) according to DC/TMD criteria, and individuals with vitamin D deficiency. Two different treatment methods were applied to the patients. One group received medical treatment with diclofenac sodium and an occlusal splint. The other group received vitamin D supplementation and an occlusal splint. The patients' mouth opening and pain scores were evaluated at four stages; before treatment, and 1 week, 4 weeks, 12 weeks after the initiation of treatment.
The study ultimately included 40 participants, with 20 patients per group. Of the participants, 3 (7.5%) were male and 37 (92.5%) were female. At the end of the study, the changes in mouth opening and VAS scores were homogeneous in both groups.
Vitamin D may serve as an alternative with anti-inflammatory and analgesic effects compared to NSAIDs.
This randomised trial was approved by the Van Yüzüncü Yıl University Faculty of Medicine Clinical Research Ethics Committee (May 18, 2022, decision no: 05). The trial was registered with the Clinical Trial Registry ( Number and date: NCT06111573, 10/31/2023).
颞下颌关节紊乱是重要的健康问题，其特征为咀嚼肌和颞下颌关节功能障碍。这些紊乱通常与压力、口腔副功能以及磨牙症等习惯有关。治疗磨牙症和其他副功能习惯可减轻肌筋膜疼痛症状。虽然磨牙症的病因尚不清楚，但压力和焦虑等心理因素以及中枢神经系统被认为会引发磨牙症。此外，血清维生素D水平低与磨牙症之间存在显著关联。本研究的目的是比较评估非甾体抗炎药治疗和补充维生素D对肌筋膜疼痛且维生素D缺乏个体症状的有效性。
本研究纳入了年龄在18至40岁之间、根据DC/TMD标准诊断为肌筋膜疼痛（MP）且维生素D缺乏的患者。对患者采用了两种不同的治疗方法。一组接受双氯芬酸钠药物治疗和咬合板治疗。另一组接受维生素D补充治疗和咬合板治疗。在治疗前、治疗开始后1周、4周、12周这四个阶段评估患者的开口度和疼痛评分。
该研究最终纳入40名参与者，每组20名患者。参与者中，3名（7.5%）为男性，37名（92.5%）为女性。研究结束时，两组的开口度和视觉模拟评分（VAS）变化是一致的。
与非甾体抗炎药相比，维生素D可能具有抗炎和镇痛作用，可作为一种替代药物。
该随机试验经凡·于泽尔居尔大学医学院临床研究伦理委员会批准（2022年5月18日，决定编号：05）。该试验已在临床试验注册中心注册（编号和日期：NCT06111573，2023年10月31日）。
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