Miyashita H, Kamaya Y, Suzuki K, Kato S, Morikawa S, Soma T, Nasu M, Munakata K, Nakagawa T, Aizawa M
Department of Dentistry and Oral Surgery, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Applied Chemistry Program, Graduate School of Science and Technology, Meiji University, Kawasaki, Japan.
J Mater Sci Mater Med. 2025 Aug 30;36(1):70. doi: 10.1007/s10856-025-06932-0.
Calcium-phosphate cement (CPC), a paste-like artificial bone, is a material form that allows minimally invasive treatment. However, CPC is not infection resistant, which may lead to surgical site infections. We recently developed a paste-like organic/inorganic hybrid artificial bone that is compatible with the bone remodeling cycle. In this study, we added silver-loaded tricalcium phosphate, which has antibacterial properties, to the hybrid CPC and fabricated a prototype "antibacterial CPC". Antibacterial and non-antibacterial CPCs were implanted into a rabbit jaw defect model in which infection could occur, and the in vivo responses were compared. In cement specimens retrieved from rabbit jaws, residual material was observed with the non-antibacterial CPC, whereas with the antibacterial CPC, almost all of the material was resorbed and replaced with host bone. These results suggest that placement of antibacterial CPC in a rabbit jaw bone defect model susceptible to bacterial infection promotes material resorption and bone formation. The antibacterial CPC developed in this study is thus a novel paste artificial bone exhibiting good bioresorption and osteogenic potential in biological hard tissues.
磷酸钙骨水泥（CPC）是一种糊状人工骨，是一种可实现微创治疗的材料形式。然而，CPC不具有抗感染性，这可能导致手术部位感染。我们最近研发了一种与骨重塑周期相容的糊状有机/无机混合人工骨。在本研究中，我们将具有抗菌性能的载银磷酸三钙添加到混合CPC中，制造出了“抗菌CPC”原型。将抗菌和非抗菌CPC植入可能发生感染的兔颌骨缺损模型中，并比较其体内反应。在从兔颌骨取出的骨水泥标本中，非抗菌CPC有残留材料，而抗菌CPC几乎所有材料都被吸收并被宿主骨替代。这些结果表明，在易受细菌感染的兔颌骨缺损模型中植入抗菌CPC可促进材料吸收和骨形成。因此，本研究中研发的抗菌CPC是一种新型糊状人工骨，在生物硬组织中表现出良好的生物吸收性和成骨潜力。
