印防己毒素对大鼠视上核神经元峰间间期的作用。

The action of picrotoxin on the interspike interval in rat supraoptic neurones.

作者信息

West D C, Thomson A M

出版信息

Neurosci Lett. 1985 Dec 4;62(2):207-11. doi: 10.1016/0304-3940(85)90356-8.

Abstract

Effects of gamma-aminobutyric acid (GABA) antagonists on cells of the supraoptic nucleus have been investigated in isolated slices of rat hypothalamus. Bicuculline had no effect on firing patterns or the minimum interspike interval. Picrotoxin reduced the minimum interspike interval and caused long-lasting bursts of high-frequency spikes, an effect that persisted even when synaptic transmission was blocked. We suggest, that in this case, picrotoxin is not acting primarily as a GABA antagonist but as a blocker of chloride channels, thereby altering the cell properties that regulate the minimum interval.

摘要

已在大鼠下丘脑离体切片中研究了γ-氨基丁酸（GABA）拮抗剂对视上核细胞的影响。荷包牡丹碱对放电模式或最小峰间间隔没有影响。印防己毒素缩短了最小峰间间隔，并引发了高频尖峰的持续爆发，即使在突触传递被阻断时这种效应仍持续存在。我们认为，在这种情况下，印防己毒素主要不是作为GABA拮抗剂起作用，而是作为氯离子通道阻滞剂起作用，从而改变调节最小间隔的细胞特性。