Lerner-Natoli M, Heaulme M, Leyris R, Biziere K, Rondouin G
Neurosci Lett. 1985 Dec 4;62(2):271-6. doi: 10.1016/0304-3940(85)90367-2.
Alterations in gamma-aminobutyric acid (GABA) metabolism have been investigated in the kindling model of epilepsy. Numerous generalized seizures were induced by amygdala-kindling stimulations in rats. One week after the last stimulation, there were no changes in GABA levels nor in the activity of enzymes responsible for the synthesis (glutamic acid decarboxylase) and catabolism (GABA transaminase and succinyl semialdehyde dehydrogenase). These results do not exclude other changes in GABA function as modifications of transport or receptors.
在癫痫的点燃模型中，已经对γ-氨基丁酸（GABA）代谢的改变进行了研究。通过对大鼠杏仁核进行点燃刺激诱发了多次全身性癫痫发作。在最后一次刺激后一周，GABA水平以及负责合成（谷氨酸脱羧酶）和分解代谢（GABA转氨酶和琥珀酰半醛脱氢酶）的酶活性均未发生变化。这些结果并不排除GABA功能的其他变化，如转运或受体的改变。
