Dunner D L, Heiber S, Perel J M
Psychopharmacology (Berl). 1977 Aug 16;53(3):305-8. doi: 10.1007/BF00492369.
The administration of large doses of probenecid has been used to study the central nervous system metabolism of catecholamines and indoleamines in patients with affective disease. It has been reported that alterations of the binding of L-tryptophan to plasma albumin binding sites occur during probenecid administration. The present study sought to determine if the administration of large doses of L-tryptophan affected probenecid concentrations in cerebrospinal fluid and/or plasma. The data indicate that during L-tryptophan treatment, plasma probenecid concentrations are reduced but that no significant alterations in cerebrospinal fluid probenecid concentrations occur. This would suggest that the kinetics of the probenecid blockade of transport of acidic biogenic amine metabolites out of cerebrospinal fluid are not altered by L-tryptophan loading.
大剂量丙磺舒已被用于研究情感性疾病患者儿茶酚胺和吲哚胺的中枢神经系统代谢。据报道，在给予丙磺舒期间，L-色氨酸与血浆白蛋白结合位点的结合发生改变。本研究旨在确定大剂量L-色氨酸的给药是否会影响脑脊液和/或血浆中丙磺舒的浓度。数据表明，在L-色氨酸治疗期间，血浆丙磺舒浓度降低，但脑脊液中丙磺舒浓度无显著变化。这表明L-色氨酸负荷不会改变丙磺舒阻止酸性生物胺代谢产物从脑脊液中转运的动力学。
