Letter to the Editor Regarding "The Safety and Efficacy of Intravenous Ibuprofen in Older Patients: A Retrospective Subgroup Analysis"-Reframing Intravenous Ibuprofen Use in Geriatric Pain Management: Insights on Safety, Stratification, and Polypharmacy.

We commend the retrospective subgroup analysis by Gan et al. for addressing a vital concern in geriatric pharmacotherapy-balancing analgesic efficacy with safety in older patients. Although their findings reinforce the utility of intravenous ibuprofen for acute postoperative pain, we offer further perspectives on patient selection, comorbid risk profiles, and polypharmacy, particularly in frail or polymorbid geriatric populations. This letter expands on practical and clinical considerations in translating these findings into real-world settings.