多分子成像显示转移性嗜铬细胞瘤病例中的肿瘤异质性及不同的诊断性能。
Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma.
作者信息
Hedeer Fredrik, Oddstig Jenny, Hallgrimson Páll, Fagher Katarina
机构信息
Department of Clinical Physiology and Nuclear Medicine, Lund University, Skåne University Hospital, Entrégatan 7, Lund, S-221 85, Sweden.
Department of Medical Radiation Physics, Lund University, Skåne University Hospital, Lund, Sweden.
出版信息
EJNMMI Rep. 2025 Sep 1;9(1):31. doi: 10.1186/s41824-025-00267-3.
A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [F]-metafluorobenzylguanidine (mFBG), [Ga]Ga-DOTA-TOC and [F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [I]-metaiodobenzylguanidine (mIBG). The methods showed different diagnostic performance, with the highest number of suspected malignant lesions detected by [F]-mFBG-PET, and revealed insights into tumour heterogeneity.
一名患有2A型多发性内分泌腺瘤病（MEN2A）且怀疑有转移性嗜铬细胞瘤的患者，接受了使用最近推出的放射性药物[F] - 间氟苄胍（mFBG）、[Ga]Ga - DOTA - TOC和[F]F - 二羟基苯丙氨酸（DOPA）的多分子正电子发射断层扫描（PET）成像以及使用[I] - 间碘苄胍（mIBG）的闪烁扫描。这些方法显示出不同的诊断性能，[F] - mFBG - PET检测到的疑似恶性病变数量最多，并揭示了肿瘤异质性的相关情况。
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