• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

多分子成像显示转移性嗜铬细胞瘤病例中的肿瘤异质性及不同的诊断性能。

Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma.

作者信息

Hedeer Fredrik, Oddstig Jenny, Hallgrimson Páll, Fagher Katarina

机构信息

Department of Clinical Physiology and Nuclear Medicine, Lund University, Skåne University Hospital, Entrégatan 7, Lund, S-221 85, Sweden.

Department of Medical Radiation Physics, Lund University, Skåne University Hospital, Lund, Sweden.

出版信息

EJNMMI Rep. 2025 Sep 1;9(1):31. doi: 10.1186/s41824-025-00267-3.

DOI:10.1186/s41824-025-00267-3
PMID:40887494
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12399497/
Abstract

A patient with multiple endocrine neoplasia 2A (MEN2A) and a suspicion of metastasized pheochromocytoma, underwent multi-molecular positron emission tomography (PET) imaging with the recently presented radiopharmaceutical [F]-metafluorobenzylguanidine (mFBG), [Ga]Ga-DOTA-TOC and [F]F-dihydroxyphenylalanine (DOPA) as well as scintigraphy with [I]-metaiodobenzylguanidine (mIBG). The methods showed different diagnostic performance, with the highest number of suspected malignant lesions detected by [F]-mFBG-PET, and revealed insights into tumour heterogeneity.

摘要

一名患有2A型多发性内分泌腺瘤病（MEN2A）且怀疑有转移性嗜铬细胞瘤的患者，接受了使用最近推出的放射性药物[F] - 间氟苄胍（mFBG）、[Ga]Ga - DOTA - TOC和[F]F - 二羟基苯丙氨酸（DOPA）的多分子正电子发射断层扫描（PET）成像以及使用[I] - 间碘苄胍（mIBG）的闪烁扫描。这些方法显示出不同的诊断性能，[F] - mFBG - PET检测到的疑似恶性病变数量最多，并揭示了肿瘤异质性的相关情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64cf/12399497/0a5c4984ba5e/41824_2025_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64cf/12399497/0a5c4984ba5e/41824_2025_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64cf/12399497/0a5c4984ba5e/41824_2025_267_Fig1_HTML.jpg

相似文献

1
Multi-molecular imaging showing tumour heterogeneity and differing diagnostic performance in a case with metastatic pheochromocytoma.多分子成像显示转移性嗜铬细胞瘤病例中的肿瘤异质性及不同的诊断性能。
EJNMMI Rep. 2025 Sep 1;9(1):31. doi: 10.1186/s41824-025-00267-3.
2
123I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma.用于诊断神经母细胞瘤的123I-间碘苄胍闪烁扫描术和18F-氟代脱氧葡萄糖正电子发射断层显像
Cochrane Database Syst Rev. 2015 Sep 29;2015(9):CD009263. doi: 10.1002/14651858.CD009263.pub2.
3
Comparison of metaiodobenzylguanidine scintigraphy with positron emission tomography in the diagnostic work-up of pheochromocytoma and paraganglioma: a systematic review.间碘苄胍闪烁扫描术与正电子发射断层扫描术在嗜铬细胞瘤和副神经节瘤诊断检查中的比较：一项系统评价
Q J Nucl Med Mol Imaging. 2013 Jun;57(2):122-33.
4
Ga-DOTATOC PET/CT in the localization of metastatic extra-adrenal paraganglioma and pheochromocytoma compared with F-DOPA PET/CT.与F-DOPA PET/CT相比，Ga-DOTATOC PET/CT在转移性肾上腺外副神经节瘤和嗜铬细胞瘤定位中的应用
Rev Esp Med Nucl Imagen Mol (Engl Ed). 2019 Mar-Apr;38(2):94-99. doi: 10.1016/j.remn.2018.09.004. Epub 2019 Jan 7.
5
Ga-DOTATOC PET/CT in the localization of head and neck paraganglioma compared with F-DOPA PET/CT and I-MIBG SPECT/CT.镓-DOTATOC PET/CT 对头颈部副神经节瘤的定位与 F-DOPA PET/CT 和 I-MIBG SPECT/CT 的比较。
Nucl Med Biol. 2019 Apr;71:47-53. doi: 10.1016/j.nucmedbio.2019.04.003. Epub 2019 Apr 29.
6
A Prospective Comparative Study of 18 F-FDOPA PET/CT Versus 123 I-MIBG Scintigraphy With SPECT/CT for the Diagnosis of Pheochromocytoma and Paraganglioma.18F-FDOPA PET/CT与123I-MIBG SPECT/CT诊断嗜铬细胞瘤和副神经节瘤的前瞻性比较研究
Clin Nucl Med. 2024 Jan 1;49(1):27-36. doi: 10.1097/RLU.0000000000004963. Epub 2023 Nov 29.
7
Comparison of 18F-fluoro-L-DOPA, 18F-fluoro-deoxyglucose, and 18F-fluorodopamine PET and 123I-MIBG scintigraphy in the localization of pheochromocytoma and paraganglioma.18F-氟-L-多巴、18F-氟脱氧葡萄糖和 18F-氟多巴 PET 与 123I-MIBG 闪烁显像在嗜铬细胞瘤和副神经节瘤定位中的比较。
J Clin Endocrinol Metab. 2009 Dec;94(12):4757-67. doi: 10.1210/jc.2009-1248. Epub 2009 Oct 28.
8
[F]MFBG PET/CT is an effective and preferable imaging modality for neuroblastoma in a prospective comparison with SSTR PET.在与生长抑素受体（SSTR）PET进行的前瞻性比较中，[F]间碘苄胍（MIBG）PET/CT是一种用于神经母细胞瘤的有效且更优的成像方式。
Eur J Nucl Med Mol Imaging. 2025 Jul 28. doi: 10.1007/s00259-025-07449-y.
9
A retrospective comparison between 68Ga-DOTA-TOC PET/CT and 18F-DOPA PET/CT in patients with extra-adrenal paraganglioma.68Ga-DOTA-TOC PET/CT 与 18F-DOPA PET/CT 对肾上腺外副神经节瘤的回顾性比较。
Eur J Nucl Med Mol Imaging. 2013 Dec;40(12):1800-8. doi: 10.1007/s00259-013-2548-y. Epub 2013 Sep 27.
10
Diagnostic Performance of the Ga-Labeled Minigastrin Analog DOTA-MGS5 in Patients with Advanced Medullary Thyroid Cancer and Other Neuroendocrine Tumors.镓标记的小胃泌素类似物DOTA-MGS5在晚期甲状腺髓样癌和其他神经内分泌肿瘤患者中的诊断性能
J Nucl Med. 2025 Sep 4. doi: 10.2967/jnumed.125.269863.

本文引用的文献

1
Performing [F]MFBG Long-Axial-Field-of-View PET/CT Without Sedation or General Anesthesia for Imaging of Children with Neuroblastoma.在无镇静或全身麻醉的情况下进行[F]MFBG长轴视野PET/CT对神经母细胞瘤患儿进行成像
J Nucl Med. 2024 Aug 1;65(8):1286-1292. doi: 10.2967/jnumed.123.267256.
2
Update on Management of Medullary Thyroid Carcinoma: Focus on Nuclear Medicine.甲状腺髓样癌治疗进展：聚焦核医学。
Semin Nucl Med. 2023 Jul;53(4):481-489. doi: 10.1053/j.semnuclmed.2023.01.003. Epub 2023 Jan 24.
3
[F] MFBG PET imaging: biodistribution, pharmacokinetics, and comparison with [I] MIBG in neural crest tumour patients.
氟代间位碘代苄胍（F）MFBG PET 成像：在神经嵴肿瘤患者中的生物分布、药代动力学和与碘代间位碘代苄胍（I）MIBG 的比较。
Eur J Nucl Med Mol Imaging. 2023 Mar;50(4):1134-1145. doi: 10.1007/s00259-022-06046-7. Epub 2022 Nov 26.
4
Overview of the 2022 WHO Classification of Paragangliomas and Pheochromocytomas.2022 年世卫组织副神经节瘤和嗜铬细胞瘤分类概述。
Endocr Pathol. 2022 Mar;33(1):90-114. doi: 10.1007/s12022-022-09704-6. Epub 2022 Mar 13.
5
Sporadic Primary Pheochromocytoma: A Prospective Intraindividual Comparison of Six Imaging Tests (CT, MRI, and PET/CT Using Ga-DOTATATE, FDG, F-FDOPA, and F-FDA).散发性嗜铬细胞瘤：六种影像学检查（CT、MRI 和使用 Ga-DOTATATE、FDG、F-FDOPA 和 F-FDA 的 PET/CT）的前瞻性个体内比较
AJR Am J Roentgenol. 2022 Feb;218(2):342-350. doi: 10.2214/AJR.21.26071. Epub 2021 Aug 25.
6
Personalized Management of Pheochromocytoma and Paraganglioma.《嗜铬细胞瘤和副神经节瘤的个体化管理》
Endocr Rev. 2022 Mar 9;43(2):199-239. doi: 10.1210/endrev/bnab019.
7
Somatostatin Receptors and Analogs in Pheochromocytoma and Paraganglioma: Old Players in a New Precision Medicine World.生长抑素受体及其类似物在嗜铬细胞瘤和副神经节瘤中的作用：精准医学世界中的老牌选手。
Front Endocrinol (Lausanne). 2021 Mar 29;12:625312. doi: 10.3389/fendo.2021.625312. eCollection 2021.
8
European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma.欧洲核医学协会实践指南/核医学与分子影像学会2019年嗜铬细胞瘤和副神经节瘤放射性核素成像程序标准
Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2112-2137. doi: 10.1007/s00259-019-04398-1. Epub 2019 Jun 29.
9
Biodistribution and Dosimetry of F-Meta-Fluorobenzylguanidine: A First-in-Human PET/CT Imaging Study of Patients with Neuroendocrine Malignancies.氟代甲苄基胍的生物分布与剂量学：神经内分泌恶性肿瘤患者的首次人体 PET/CT 成像研究。
J Nucl Med. 2018 Jan;59(1):147-153. doi: 10.2967/jnumed.117.193169. Epub 2017 Jul 13.
10
PET/CT comparing (68)Ga-DOTATATE and other radiopharmaceuticals and in comparison with CT/MRI for the localization of sporadic metastatic pheochromocytoma and paraganglioma.PET/CT比较（68）镓-多柔比星和其他放射性药物，并与CT/MRI比较用于散发性转移性嗜铬细胞瘤和副神经节瘤的定位。
Eur J Nucl Med Mol Imaging. 2016 Sep;43(10):1784-91. doi: 10.1007/s00259-016-3357-x. Epub 2016 Mar 21.