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颈动脉斑块内新生血管形成的超声评估现状与进展:一项系统综述

Current status and advances in ultrasound evaluation of neovascularization within carotid artery plaques: a systematic review.

作者信息

Yang Yang, Liu Fangqin, Yan Jiaojun, Luo Yunhao, Huang Qiuyun, Qiao Lang

机构信息

School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Department of Ultrasound, Chengdu Sixth People's Hos pital, Chengdu, China.

出版信息

Cardiovasc Ultrasound. 2025 Sep 1;23(1):19. doi: 10.1186/s12947-025-00356-0.


DOI:10.1186/s12947-025-00356-0
PMID:40887612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12400744/
Abstract

Vulnerable plaques are significant risk factors for acute ischemic events, and intraplaque neovascularization (IPN) is an important indicator for evaluating plaque vulnerability. This review summarizes the importance of IPN in the assessment of carotid plaque vulnerability, the current status of ultrasound examination of IPN, and the technical advancements in ultrasound imaging of IPN, These techniques include: Superb micro-vascular imaging; Contrast-enhanced ultrasound; Plane wave ultra-sensitive blood flow imaging; Ultrasound-targeted microbubble destruction; Ultrasound Super-Resolution Imaging. Aiming to provide a reference for the prevention and treatment of ischemic cardiovascular and cerebrovascular events.

摘要

易损斑块是急性缺血性事件的重要危险因素,斑块内新生血管形成(IPN)是评估斑块易损性的重要指标。本综述总结了IPN在评估颈动脉斑块易损性中的重要性、IPN超声检查的现状以及IPN超声成像的技术进展。这些技术包括:超微血管成像;超声造影;平面波超敏感血流成像;超声靶向微泡破坏;超声超分辨率成像。旨在为缺血性心脑血管事件的防治提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a3d/12400744/9b66fab04541/12947_2025_356_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a3d/12400744/a30538c54bc3/12947_2025_356_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a3d/12400744/9b66fab04541/12947_2025_356_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a3d/12400744/a30538c54bc3/12947_2025_356_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a3d/12400744/9b66fab04541/12947_2025_356_Fig2_HTML.jpg

相似文献

[1]
Current status and advances in ultrasound evaluation of neovascularization within carotid artery plaques: a systematic review.

Cardiovasc Ultrasound. 2025-9-1

[2]
Effect of pharmacologic anti-atherosclerotic therapy on carotid intraplaque neovascularization: A systematic review.

J Clin Lipidol. 2023

[3]
Carotid Plaque Neovascularization Detected With Superb Microvascular Imaging Ultrasound Without Using Contrast Media.

Stroke. 2019-9-12

[4]
Advanced ultrasound methods in assessment of carotid plaque instability: a prospective multimodal study.

BMC Neurol. 2020-1-29

[5]
Ultrasound Characteristics of Symptomatic Carotid Plaques: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis. 2015

[6]
Carotid Intraplaque neovascularization correlates with coronary atherosclerotic plaque, vulnerability detected by intracoronary optical coherence tomography.

Int J Cardiol. 2025-10-15

[7]
[Value of Superb Micro-vascular Imaging in Diagnosing Carotid Artery Vulnerable Plaque].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018-8-30

[8]
Evaluation of Intraplaque Neovascularization Using Superb Microvascular Imaging and Contrast-Enhanced Ultrasonography.

J Stroke Cerebrovasc Dis. 2018-9

[9]
Progress of Ultrasound Techniques in the Evaluation of Carotid Vulnerable Plaque Neovascularization.

Cerebrovasc Dis. 2024

[10]
Blood Flow Turbulence Measured by High-frame-rate Vector Flow Imaging Conduced to Investigating Advanced Carotid Plaque Vulnerability.

Ultrasound Med Biol. 2025-10

本文引用的文献

[1]
The value of contrast-enhanced ultrasound in assessing carotid plaque vulnerability and predicting stroke risk.

Sci Rep. 2025-2-18

[2]
Quantitative characterisation of carotid atherosclerotic plaque neovascularisation using contrast-enhanced ultrasound imaging: A feasibility study.

Med J Malaysia. 2025-1

[3]
Assessment of microvascular flow in human atherosclerotic carotid plaques using ultrasound localization microscopy.

EBioMedicine. 2025-1

[4]
Neovascularization as a Leading Mechanism of Intraplaque Hemorrhage and Carotid Plaque Destabilization: A Narrative Review.

Curr Vasc Pharmacol. 2024

[5]
Super-Resolution US Imaging of Focal Nodular Hyperplasia.

Radiology. 2024-4

[6]
Super-Resolution Ultrasound Imaging for Monitoring the Therapeutic Efficacy of a Vascular Disrupting Agent in an Animal Model of Breast Cancer.

J Ultrasound Med. 2024-6

[7]
3-D Super-Resolution Ultrasound Imaging for Monitoring Early Changes in Breast Cancer after Treatment with a Vascular-Disrupting Agent.

IEEE Int Ultrason Symp. 2021-9

[8]
Study on the Consistency of Angiogenesis in Carotid Plaque Evaluated by Contrast-Enhanced Ultrasound and Superb Microvascular Imaging and Its Correlation With Stroke Occurrence.

J Ultrasound Med. 2024-4

[9]
Diagnostic accuracy of superb microvascular imaging for detecting intraplaque neovascularization: a systematic review and meta-analysis.

Cardiovasc Diagn Ther. 2023-10-31

[10]
Associations of plaque morphology and location with Intraplaque neovascularization in the carotid artery by contrast-enhanced ultrasound imaging.

Front Neurol. 2023-5-11

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