Kwon Seong Soon, Jeong Sun Young, Lee Min-Young, Kim Kyoung Ha, Lee Namsu, Won Jong-Ho, Yoon Seug Yun
Division of Cardiology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Seoul, Korea.
Division of Hematology & Medical Oncology, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, 59 Daesagwan-Ro, Yongsan-Gu, Seoul, 04401, Republic of Korea.
Blood Res. 2025 Sep 1;60(1):48. doi: 10.1007/s44313-025-00098-y.
Prevention of vascular events is the main objective in patients with polycythemia vera (PV) or essential thrombocythemia (ET). Carotid ultrasonography (USG) is a safe and noninvasive diagnostic tool that can be used to stratify cardiovascular and stroke risks. In our previous study, carotid plaque burden was significantly higher in patients with PV/ET than in the general population. This study aimed to determine changes in carotid plaques in patients with PV/ET.
We retrospectively evaluated the medical records of patients with ET/PV who had undergone carotid USG at least twice.
Of the 56 patients, 30 had PV and 26 had ET. The carotid plaque score was increased in the follow-up carotid USG compared with that in the initial carotid USG (3.38 ± 1.47 vs. 3.73 ± 1.46, p = 0.0139). The carotid plaque burden at the time of follow-up carotid USG showed no significant differences in patients with a complete hematologic response (CHR); however, it significantly worsened in patients who failed to achieve CHR.
We confirmed that the carotid plaque burden persisted during follow-up in patients with PV/ET. A CHR may prevent an increase in carotid plaque burden.
预防血管事件是真性红细胞增多症（PV）或原发性血小板增多症（ET）患者的主要目标。颈动脉超声检查（USG）是一种安全且无创的诊断工具，可用于对心血管和中风风险进行分层。在我们之前的研究中，PV/ET患者的颈动脉斑块负担明显高于一般人群。本研究旨在确定PV/ET患者颈动脉斑块的变化情况。
我们回顾性评估了至少接受过两次颈动脉USG检查的ET/PV患者的病历。
56例患者中，30例患有PV，26例患有ET。与初次颈动脉USG相比，随访时的颈动脉斑块评分有所增加（3.38±1.47对3.73±1.46，p = 0.0139）。在完全血液学缓解（CHR）的患者中，随访时的颈动脉斑块负担无显著差异；然而，未实现CHR的患者中，颈动脉斑块负担显著恶化。
我们证实PV/ET患者在随访期间颈动脉斑块负担持续存在。CHR可能会预防颈动脉斑块负担的增加。
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