非编码RNA在癌症诊断和治疗中发挥关键作用。
Non-coding RNAs as key player in cancer diagnosis and treatment.
作者信息
Majka Marcin
机构信息
Department of Transplantation, Institute of Pediatrics, Jagiellonian University, Krakow, Poland.
出版信息
FEBS Open Bio. 2025 Sep;15(9):1380-1382. doi: 10.1002/2211-5463.70088.
Most of the human genome is transcribed into noncoding RNAs (ncRNAs), which although do not encode proteins, are often involved in key cellular processes. Recent technological advances have accelerated the discovery of ncRNA as well as our understanding of ncRNAs as cancer biomarkers and targets. In this "In the Limelight" special issue of FEBS Open Bio, four review articles by leading experts provide an overview of the role of ncRNAs in cancer, from their association to liver cancer to their role as oncogenes in head and neck squamous cell carcinoma (HNSCC).
人类基因组的大部分转录为非编码RNA（ncRNA），这些RNA虽然不编码蛋白质，但常常参与关键的细胞过程。最近的技术进步加速了ncRNA的发现，也加深了我们对ncRNA作为癌症生物标志物和靶点的理解。在本期《FEBS Open Bio》的“聚焦”特刊中，四位顶尖专家撰写的综述文章概述了ncRNA在癌症中的作用，从它们与肝癌的关联到它们在头颈部鳞状细胞癌（HNSCC）中作为癌基因的作用。
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