Ababneh Sokiyna, Siyam Ali A Abu, Alzoubi Majdi M, Al-Sawalha Nour A, Al Sukhni Farah F, Al Rahbeni Tahani, Al-Mugheed Khalid, Farghaly Abdelaliem Sally Mohammed
Department of Allied Medical Sciences, Zarqa University College, Al-Balqa Applied University, Zarqa, Jordan.
Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Jadara University, P.O. Box 733, Irbid, 22110, Jordan.
Sci Rep. 2025 Sep 2;15(1):32267. doi: 10.1038/s41598-025-07728-6.
Research on health-related quality of life (HRQoL) among thalassemia patients in Jordan remains limited. This study aimed to evaluate HRQoL outcomes in patients with thalassemia and examine associations with psychosocial, medical, and clinical factors. A cross-sectional study was conducted among β-thalassemia major patients attending the Thalassemia Unit at Princess Rahma Educational Hospital for Children. HRQoL was assessed using a validated Arabic version of the Medical Outcomes Study Short Form (SF-36). A total of 285 patients were enrolled, with a mean age of 20.23 years; 55.1% were male. Lower mental health scores were associated with male gender, higher education, and non-smoking status. Poor physical functioning was linked to male gender, smoking, and not receiving anticoagulant therapy. Lower pain scores were observed among males and those not on anticoagulants. Vitality was significantly lower in males. Absence of comorbidities was linked to better role functioning, while non-smoking and higher income were associated with improved general health perception. Male gender, lower income, absence of splenectomy, and not using anticoagulant therapy were associated with poorer HRQoL outcomes. Overall, male patients reported lower HRQoL than females. Targeted national healthcare strategies are essential to enhance HRQoL among thalassemia patients in Jordan.
约旦地中海贫血患者健康相关生活质量（HRQoL）的研究仍然有限。本研究旨在评估地中海贫血患者的HRQoL结果，并探讨其与心理社会、医学和临床因素的关联。对拉赫玛公主儿童医院地中海贫血科的重型β地中海贫血患者进行了一项横断面研究。使用经过验证的阿拉伯语版医学结局研究简表（SF-36）评估HRQoL。共纳入285例患者，平均年龄20.23岁；55.1%为男性。较低的心理健康得分与男性性别、高等教育和不吸烟状态相关。身体功能差与男性性别、吸烟和未接受抗凝治疗有关。男性和未接受抗凝治疗者的疼痛得分较低。男性的活力显著较低。无合并症与更好的角色功能相关，而不吸烟和较高收入与改善总体健康感知相关。男性性别、低收入、未进行脾切除术和未使用抗凝治疗与较差的HRQoL结果相关。总体而言，男性患者报告的HRQoL低于女性。有针对性的国家医疗保健策略对于提高约旦地中海贫血患者的HRQoL至关重要。
