肠内分泌细胞：微生物群-肠道-大脑通讯的守门人。

Enteroendocrine cells: the gatekeepers of microbiome-gut-brain communication.

作者信息

Grundeken Esmée, El Aidy Sahar

机构信息

Department of Microbiome Engineering, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands.

Amsterdam Microbiome Expert Centre, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, Amsterdam, Netherlands.

出版信息

NPJ Biofilms Microbiomes. 2025 Sep 1;11(1):179. doi: 10.1038/s41522-025-00810-x.

DOI:10.1038/s41522-025-00810-x

PMID:40890205

Abstract

Enteroendocrine cells (EECs) are gut epithelial hormone-secreting cells, influenced by diet and the microbiome. EECs regulate local gastrointestinal functions and systemic signalling, including communication with the brain, while being linked to various diseases, yet their systemic integration remains underexplored. This review examines the metabolic and systemic roles of EECs, focusing on interactions with dietary components, the microbiome, and disease pathways, while identifying key research gaps to guide future studies.

摘要

肠内分泌细胞（EECs）是肠道上皮中分泌激素的细胞，受饮食和微生物群的影响。EECs调节局部胃肠功能和全身信号传导，包括与大脑的通讯，同时与多种疾病相关，但其全身整合仍未得到充分研究。本综述探讨了EECs的代谢和全身作用，重点关注其与饮食成分、微生物群和疾病途径的相互作用，同时确定关键的研究空白以指导未来的研究。