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透视引导下输卵管再通术后的妊娠结局:自然受孕与宫腔内人工授精的比较——一项回顾性队列研究

Pregnancy outcomes following fluoroscopy-guided tubal recanalization: a comparison of spontaneous conception and intrauterine insemination-a retrospective cohort study.

作者信息

Karadag Ceyda, Karadag Burak, Kesen Emine Yildiz Kugu, Gürses Cemil

机构信息

Department of Obstetrics and Gynecology, Saglık Bilimleri University Antalya City Hospital, Antalya, Turkey.

Department of Obstetrics and Gynecology, Saglık Bilimleri University Antalya Training and Research Hospital, Antalya, Turkey.

出版信息

Sci Rep. 2025 Sep 1;15(1):32141. doi: 10.1038/s41598-025-17762-z.

Abstract

To evaluate and compare pregnancy outcomes following successful fluoroscopy-guided tubal recanalization (FGTR), focusing on spontaneous conception versus intrauterine insemination (IUI). This retrospective cohort study included 139 women aged 21-40 years who underwent FGTR for tubal occlusion between January 2021 and May 2024. After exclusions, 80 women attempted natural conception, and 59 underwent IUI with ovarian stimulation. Groups were compared in terms of clinical pregnancy rates, time to conception, and post-procedure tubal patency. Clinical pregnancy rates were similar between spontaneous conception (51.2%) and IUI (57.6%) groups (p = 0.976). Mean time to conception did not differ significantly (6.4 ± 2.8 vs. 5.9 ± 2 months, p = 0.360). No pregnancies occurred in women with bilateral distal obstruction, whereas proximal occlusions (unilateral or bilateral) were associated with higher pregnancy rates. Six-month follow up HSG demonstrated that bilateral tubal patency correlated with greater conception likelihood. In women with tubal factor infertility who achieve patency after FGTR, spontaneous conception and IUI yield comparable pregnancy outcomes and similar time to conception. Expectant management may be a cost-effective first-line approach, reserving IUI or IVF for cases without conception within a reasonable timeframe. The site of tubal obstruction and patency status should guide individualized post-FGTR fertility planning.

摘要

评估和比较在透视引导下输卵管再通术(FGTR)成功后的妊娠结局,重点关注自然受孕与宫内人工授精(IUI)。这项回顾性队列研究纳入了139名年龄在21至40岁之间的女性,她们在2021年1月至2024年5月期间因输卵管阻塞接受了FGTR。排除相关因素后,80名女性尝试自然受孕,59名接受了促排卵的IUI。对两组在临床妊娠率、受孕时间和术后输卵管通畅情况方面进行了比较。自然受孕组(51.2%)和IUI组(57.6%)的临床妊娠率相似(p = 0.976)。平均受孕时间无显著差异(6.4±2.8个月 vs. 5.9±2个月,p = 0.360)。双侧远端阻塞的女性未发生妊娠,而近端阻塞(单侧或双侧)与较高的妊娠率相关。术后6个月的子宫输卵管造影(HSG)显示,双侧输卵管通畅与更高的受孕可能性相关。在FGTR后实现输卵管通畅的输卵管因素不孕症女性中,自然受孕和IUI产生的妊娠结局相当,受孕时间相似。期待管理可能是一种具有成本效益的一线方法,对于在合理时间内未受孕的病例保留IUI或体外受精(IVF)。输卵管阻塞部位和通畅状态应指导FGTR术后的个体化生育计划。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a432/12402183/9007354fbb7c/41598_2025_17762_Fig1_HTML.jpg

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