Magagi Larwanou Harouna, Lagare Adamou, Bowo-Ngandji Arnol, Hassane Fatimata, Maiga Abdoulaye Zeidou, Issa Moussa, Ibrahim Alkassoum, Eric Adehossi, Zoubeirou Alzouma Maiyaki
Centre de Recherche Médicale et Sanitaire, 634 Boulevard de la Nation YN034, Niamey, BP: 10887, Niger.
Faculté des Sciences de la Santé, Université Abdou Moumouni, Niamey, Niger.
Infect Agent Cancer. 2025 Sep 1;20(1):62. doi: 10.1186/s13027-025-00659-x.
Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide. Several studies have examined HPV prevalence in West Africa, but comprehensive regional estimates remain unavailable. This study estimates the overall prevalence and genotype distribution of HPV in West African populations.
We conducted a systematic search in Medline, Embase, Global Health, Web of Science, and Africa Index Medicus for articles published up to March 5, 2024. We estimated pooled HPV prevalence using a random-effects model. The Hoy et al. tool assessed the risk of bias, while the I² test measured between-study heterogeneity. Egger's regression test evaluated publication bias. The study was registered with PROSPERO (CRD42023463042).
The analysis included 145 studies from 12 West African countries, comprising 71,324 participants. The pooled prevalence of HPV was 42.3% (95% CI: 38.5-46.1%), with significant heterogeneity (I² = 99.0%; P < 0.001). HPV prevalence varied across population subgroups, with a significantly higher pooled prevalence of 81.4% (95% CI: 68.2-91.8%) among women with cervical cancer. Egger's test did not indicate significant publication bias (P > 0.05). Among high-risk HPV genotypes, HPV-16 (19.9%, 95% CI: 15.9-24.1%) and HPV-82 (18.9%, 95% CI: 7.5-33.7%) were the most prevalent. Among low-risk genotypes, HPV-81 was the most common, with a prevalence of 12.9% (95% CI: 7.1-20.0%).
Human papillomavirus prevalence is high in West Africa, with diverse genotypes, including several with oncogenic potential. Targeted health interventions, including vaccination programs and enhanced screening efforts, are recommended to reduce HPV burden in this region.
人乳头瘤病毒（HPV）是全球最常见的性传播感染之一。多项研究已对西非地区的HPV流行情况进行了调查，但仍缺乏全面的区域估计数据。本研究旨在估计西非人群中HPV的总体流行率和基因型分布。
我们在Medline、Embase、Global Health、Web of Science和Africa Index Medicus数据库中进行了系统检索，纳入截至2024年3月5日发表的文章。我们使用随机效应模型估计合并的HPV流行率。Hoy等人的工具评估了偏倚风险，而I²检验衡量了研究间的异质性。Egger回归检验评估了发表偏倚。该研究已在PROSPERO（CRD42023463042）注册。
分析纳入了来自12个西非国家的145项研究，共71,324名参与者。HPV的合并流行率为42.3%（95%CI：38.5-46.1%），存在显著异质性（I²=99.0%；P<0.001）。HPV流行率在不同人群亚组中有所差异，宫颈癌女性的合并流行率显著更高，为81.4%（95%CI：68.2-91.8%）。Egger检验未显示显著的发表偏倚（P>0.05）。在高危HPV基因型中，HPV-16（19.9%，95%CI：15.9-24.1%）和HPV-82（18.9%，95%CI：7.5-33.7%）最为常见。在低危基因型中，HPV-81最常见，流行率为12.9%（95%CI：7.1-20.0%）。
西非地区人乳头瘤病毒流行率较高，基因型多样，包括几种具有致癌潜力的基因型。建议采取有针对性的健康干预措施，包括疫苗接种计划和加强筛查力度，以减轻该地区的HPV负担。
