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用于成人代谢功能障碍相关脂肪性肝病的胆汁酸

Bile acids for metabolic dysfunction-associated steatotic liver disease in adults.

作者信息

Ashmawy Rehab E, Blyuss Oleg, Nikolova Dimitrinka, Pavlov Chavdar S, Gluud Christian, Andrenacci Paola J

机构信息

Faculty of Medicine, Helwan University, Cairo, Egypt.

Wolfson Institute of Population Health, Queen Mary University of London, London, UK.

出版信息

Cochrane Database Syst Rev. 2025 Sep 2;9(9):CD014850. doi: 10.1002/14651858.CD014850.

Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To evaluate the benefits and harms of oral bile acid-based therapies versus no intervention or placebo, or versus a different bile acid-based therapy, at any dose or regimen, in adults diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD).

摘要

这是一项Cochrane系统评价(干预措施)的方案。目标如下:评估在任何剂量或治疗方案下,口服胆汁酸类疗法与不干预或安慰剂相比,或与不同的胆汁酸类疗法相比,对诊断为代谢功能障碍相关脂肪性肝病(MASLD)的成年人的益处和危害。

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本文引用的文献

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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review.
J Obes Metab Syndr. 2023 Sep 30;32(3):197-213. doi: 10.7570/jomes23052. Epub 2023 Sep 13.
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Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis.
Cell Metab. 2023 Oct 3;35(10):1752-1766.e8. doi: 10.1016/j.cmet.2023.07.011. Epub 2023 Aug 16.
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The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review.
Hepatology. 2023 Apr 1;77(4):1335-1347. doi: 10.1097/HEP.0000000000000004. Epub 2023 Jan 3.

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