苯丙胺及其氟化类似物对小鼠运动和探索活动影响的比较。
Comparison of the effects of amphetamine and a fluorinated analogue on locomotion and exploratory activity in the mouse.
作者信息
Dubin R E, Reiffenstein R J, Baker G B, Coutts R T, Benderly A
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):681-5. doi: 10.1016/0278-5846(85)90040-5.
(+)-Amphetamine (AM) and its fluorinated analogue (+)-2-amino-3-fluoro-1-phenylpropane (fluoroamphetamine, FAM) were compared with regard to their effects on locomotor and exploratory activity in mice. Both drugs caused a reduction in spontaneous exploration, but this effect was more marked with FAM than with AM at 1 h after injection. Both compounds increased locomotor activity 10 min after injection, but FAM had sedative effects after 1 h, while AM continued to be stimulatory.
将（+）-苯丙胺（AM）及其氟化类似物（+）-2-氨基-3-氟-1-苯基丙烷（氟苯丙胺，FAM）在对小鼠运动和探索活动的影响方面进行了比较。两种药物都导致自发探索减少，但在注射后1小时，FAM的这种作用比AM更明显。两种化合物在注射后10分钟均增加了运动活性，但FAM在1小时后具有镇静作用，而AM仍具有刺激作用。
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