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Behavioral and neurochemical effects of (-)- and (+/-)-cathinone: dose-response and time-course.

作者信息

Nielsen J A, Schechter M D

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(5-6):739-43. doi: 10.1016/0278-5846(85)90052-1.

DOI:10.1016/0278-5846(85)90052-1
PMID:4089202
Abstract

The purpose of the present study was to compare (-)-cathinone and its analogue (+/-)-cathinone using behavioral and neurochemical measures. Rats were trained to discriminate between 0.6 mg/kg (-)- or (+/-)-cathinone and saline in a food-motivated, two-lever operant task. In addition, concentrations of dopamine, norepinephrine, 5-hydroxytryptamine and their major metabolites were analyzed in the nuclei accumbens and septi lateralis. The results suggest that (-)- and (+/-)-cathinone have similar effects on behavior and neurochemistry with (-)-cathinone being more potent.

摘要

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