Alpidovskaya O V, Malyshev I I, Romanova L P
I. N. Ulianov Chuvash State University, Cheboksary, Russia.
Mari State University, Yoshkar-Ola, Russia.
Bull Exp Biol Med. 2025 Sep 2. doi: 10.1007/s10517-025-06464-1.
Male Wistar rats were subjected to physical exercise of mild (group 1), moderate (group 2), and high (group 3) intensity. Ten swimming sessions were conducted, after which the animals were sacrificed (immediately and 30 days after the last session). Liver samples were studied by histological methods; the expression of the tgfb1 gene and the level of TGF-β1 in the liver were evaluated. Moderate degenerative processes were observed in the liver of rats with mild to moderate physical activity, and no significant changes were detected in the expression of tgfb1 gene and TGF-β1 content in the liver. In case of hard physical exercise, degenerative changes, necrosis, and cell infiltration were observed in the liver, and the level of TGF-β1 decreased. In 30 days after the last swimming session, an increase in both the level of TGF-β1 in the cytoplasmic fraction of the liver and the expression of the tgfb1 gene was observed.
将雄性Wistar大鼠分为轻度（第1组）、中度（第2组）和高强度（第3组）体育锻炼组。进行了十次游泳训练，之后处死动物（最后一次训练后立即处死和30天后处死）。通过组织学方法研究肝脏样本；评估肝脏中tgfb1基因的表达和TGF-β1的水平。在进行轻度至中度体育活动的大鼠肝脏中观察到中度退行性变化，肝脏中tgfb1基因的表达和TGF-β1含量未检测到显著变化。在进行高强度体育锻炼的情况下，肝脏中观察到退行性变化、坏死和细胞浸润，且TGF-β1水平降低。在最后一次游泳训练30天后，观察到肝脏细胞质部分中TGF-β1水平和tgfb1基因表达均增加。
