Wang Yu, Cao Guang-Ping, Qu Xin-Jian, Liu Yong-Hong, Yi Xiang-Xi, Gao Cheng-Hai, Bai Meng
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China.
Guangxi Key Laboratory of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, P.R. China.
J Nat Prod. 2025 Sep 26;88(9):2239-2246. doi: 10.1021/acs.jnatprod.5c00752. Epub 2025 Sep 2.
Three new arthrichitin derivatives I-K (-) and three known congeners (-) were isolated from a coculture of mangrove-derived fungi sp. and sp. using H NMR-guided fractionation. Their structures were determined by comprehensive spectroscopic analysis (1D/2D NMR, HRESIMS, ESI-MS/MS), Marfey's analysis, DP4+ probability, and experimental/computed ECD comparison. All compounds were evaluated for antibacterial effects and cytotoxicity. Notably, compounds and showed weak cytotoxicity against MHCC-97H cells (IC = 20.1 ± 0.9 and 25.8 ± 0.4 μM, respectively). Compound exhibited potent anti-BPH activity (IC = 0.36 ± 0.02 μM).
通过¹H NMR引导分级分离，从红树林来源的真菌sp.和sp.的共培养物中分离出三种新的节肢壳多糖衍生物I - K（-）和三种已知的同系物（-）。通过综合光谱分析（一维/二维核磁共振、高分辨电喷雾电离质谱、电喷雾串联质谱）、马尔费伊分析法、DP4 +概率以及实验/计算的电子圆二色光谱比较确定了它们的结构。对所有化合物进行了抗菌效果和细胞毒性评估。值得注意的是，化合物和对MHCC - 97H细胞显示出较弱的细胞毒性（IC分别为20.1±0.9和25.8±0.4μM）。化合物表现出强效的抗良性前列腺增生活性（IC = 0.36±0.02μM）。
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