New Antibacterial Phenone Derivatives Asperphenone A-C from Mangrove-Derived Fungus Aspergillus sp. YHZ-1.

Marine fungi are a promising source of novel bioactive natural products with diverse structure. In our search for new bioactive natural products from marine fungi, three new phenone derivatives, asperphenone A-C (-), have been isolated from the ethyl acetate extract of the fermentation broth of the mangrove-derived fungus, sp. YHZ-1. The chemical structures of these natural products were elucidated on the basis of mass spectrometry, one- and two-dimensional NMR spectroscopic analysis and asperphenone A and B were confirmed by single-crystal X-ray crystallography. Compounds and exhibited weak antibacterial activity against four Gram-positive bacteria, CMCC(B) 26003, ATCC19615, CICC 10283 and , with the MIC values higher than 32.0 µM.