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Immunotherapy Resistance in Lethal Prepubescent Spitz Melanoma With Promoter Variant.

作者信息

Groisser Alissa, John Liny, Kirkorian A Yasmine, Gulino Sam P, Rossi Christopher T, Vyas Pranav K, Gagan Jeffrey, Raffeld Mark, Aldape Kenneth, Barr Frederic G, Xi Liqiang, Lee Ina, Ferrone Christina K, Pack Svetlana D, Kaplan Rosandra N, Goldstein Alisa M, Barnhill Raymond, Yohe Marielle, Sargen Michael R

机构信息

Division of Oncology, Children's National, Washington, DC.

Division of Dermatology, Children's National, Washington, DC.

出版信息

JCO Precis Oncol. 2025 Sep;9:e2500407. doi: 10.1200/PO-25-00407. Epub 2025 Sep 2.

DOI:10.1200/PO-25-00407
PMID:40893052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12407240/
Abstract
摘要

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本文引用的文献

1
Clinicopathologic Features, Management, and Outcomes Of Pediatric CRTC1::TRIM11 and MED15::ATF1 Tumors With Spitzoid Morphology: A Case Series.具有Spitz样形态的儿童CRTC1::TRIM11和MED15::ATF1肿瘤的临床病理特征、管理及预后：病例系列
Pediatr Blood Cancer. 2025 Aug;72(8):e31814. doi: 10.1002/pbc.31814. Epub 2025 May 19.
2
A Clinical, Morphologic, and Molecular Comparison of Bonafide Spitz Melanomas and Atypical Spitz Tumors in the Pediatric Population.儿童人群中真性斯皮茨黑色素瘤与非典型斯皮茨肿瘤的临床、形态学及分子比较
Am J Surg Pathol. 2025 Jul 1;49(7):663-673. doi: 10.1097/PAS.0000000000002381. Epub 2025 Apr 24.
3
Evaluation and Surgical Management of Pediatric Cutaneous Melanoma and Atypical Spitz and Non-Spitz Melanocytic Tumors (Melanocytomas): A Report From Children's Oncology Group.儿童皮肤黑色素瘤、非典型斯皮茨瘤及非斯皮茨黑色素细胞肿瘤（黑素细胞瘤）的评估与外科治疗：来自儿童肿瘤协作组的报告
J Clin Oncol. 2025 Mar 20;43(9):1157-1167. doi: 10.1200/JCO.24.01154. Epub 2024 Oct 4.
4
Shortened progression free and overall survival to immune-checkpoint inhibitors in BRAF-, RAS- and NF1- ("Triple") wild type melanomas.BRAF、RAS 和 NF1（“三重”）野生型黑色素瘤中免疫检查点抑制剂的无进展生存期和总生存期缩短。
Eur J Cancer. 2024 Sep;208:114208. doi: 10.1016/j.ejca.2024.114208. Epub 2024 Jul 6.
5
CRTC1::TRIM11 cutaneous tumor: An update with local recurrence and lung metastasis in a pediatric patient.CRTC1::TRIM11皮肤肿瘤：一名儿科患者局部复发和肺转移的最新情况
J Cutan Pathol. 2024 Mar;51(3):181-183. doi: 10.1111/cup.14556. Epub 2023 Nov 9.
6
Association of germline variants in telomere maintenance genes ( and ) with spitzoid morphology in familial melanoma: A multi-center case series.端粒维持基因（和）中的种系变异与家族性黑色素瘤中的Spitzoid形态的关联：一项多中心病例系列研究。
JAAD Int. 2023 Jan 30;11:43-51. doi: 10.1016/j.jdin.2023.01.013. eCollection 2023 Jun.
7
Circulating tumor DNA-based molecular residual disease detection for treatment monitoring in advanced melanoma patients.基于循环肿瘤 DNA 的分子残留疾病检测在晚期黑色素瘤患者治疗监测中的应用。
Cancer. 2023 Jun 1;129(11):1723-1734. doi: 10.1002/cncr.34716. Epub 2023 Mar 4.
8
A Phase I/II Trial of Nivolumab plus Ipilimumab in Children and Young Adults with Relapsed/Refractory Solid Tumors: A Children's Oncology Group Study ADVL1412.纳武利尤单抗联合伊匹单抗治疗儿童和青年复发性/难治性实体瘤的 I/II 期试验：儿童肿瘤学组 ADVL1412 研究。
Clin Cancer Res. 2022 Dec 1;28(23):5088-5097. doi: 10.1158/1078-0432.CCR-22-2164.
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A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance.黑色素瘤的十年检查点阻断免疫治疗：了解免疫敏感性和耐药性的分子基础。
Nat Immunol. 2022 May;23(5):660-670. doi: 10.1038/s41590-022-01141-1. Epub 2022 Mar 3.
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Histologic features of melanoma associated with germline mutations of CDKN2A, CDK4, and POT1 in melanoma-prone families from the United States, Italy, and Spain.美国、意大利和西班牙黑色素瘤易感家族中与 CDKN2A、CDK4 和 POT1 种系突变相关的黑色素瘤的组织学特征。
J Am Acad Dermatol. 2020 Sep;83(3):860-869. doi: 10.1016/j.jaad.2020.03.100. Epub 2020 Apr 10.