Boney Colton, Zakala Alyssa, League Aimee, Hassoun Ali
The Alabama College of Osteopathic Medicine, 445 Health Sciences Blvd, Dothan, AL, 36303, USA.
Huntsville Hospital, 101 Sivley Rd SW, Huntsville, AL, 35801, USA.
Med Mycol Case Rep. 2025 Aug 9;49:100723. doi: 10.1016/j.mmcr.2025.100723. eCollection 2025 Sep.
remains the most common cause of systemic fungal infections in the United States, with severe cases occurring in older adults, immunosuppressed individuals, and those with lung disease. Despite its prevalence in systemic and pulmonary illness, histoplasmosis endocarditis is an unlikely source of mycotic endocarditis, with limited updated guidelines on antifungal therapy. We present a case of artificial valve endocarditis requiring surgery and antifungal therapy. Isavuconazole was selected through shared decision-making due to concerns about the tolerability of traditional agents. The patient was successfully treated with a combination of aortic valve replacement and isavuconazole therapy.
在美国，它仍然是系统性真菌感染最常见的病因，严重病例发生在老年人、免疫抑制个体以及患有肺部疾病的人群中。尽管组织胞浆菌病在全身和肺部疾病中普遍存在，但组织胞浆菌性心内膜炎不太可能是真菌性心内膜炎的病因，关于抗真菌治疗的最新指南有限。我们报告一例需要手术和抗真菌治疗的人工瓣膜心内膜炎病例。由于担心传统药物的耐受性，通过共同决策选择了艾沙康唑。患者通过主动脉瓣置换术和艾沙康唑治疗相结合而成功治愈。
