Anushya Vardhini V, Sowmiya S, Abdul Sameer S, Sakthi R, Divya R, Monisha A
Department of Pharmacology, Faculty of Pharmacy, Dr. MGR Educational and Research Institute, Velappanchavadi, Chennai 77, India.
Department of Pharmaceutics, Faculty of Pharmacy, Dr. MGR Educational and Research Institute, Velappanchavadi, Chennai 77, India.
IBRO Neurosci Rep. 2025 Aug 15;19:456-470. doi: 10.1016/j.ibneur.2025.08.012. eCollection 2025 Dec.
Myelin degeneration is a hallmark of multiple sclerosis, a chronic, autoimmune neurological condition that alters Central Nervous System communication. Despite the fact that the pathophysiology of multiple sclerosis is multifactorial and not fully understood, new research indicates that reducing oxidative stress and inflammation may have therapeutic advantages. A class of phytoestrogens called isoflavones, which are mostly present in soy and other legumes, have drawn interest because of their possible anti-inflammatory and neuroprotective properties. A comprehensive literature review was performed covering the period from 2000 to 2024, utilizing various databases such as PubMed, Scopus, ScienceDirect, and Google Scholar. This process involved the use of specific search terms and Boolean operators, including "isoflavones" AND "multiple sclerosis," "phytoestrogens" AND "neuroprotection," and "soy isoflavones" AND "autoimmune diseases," to locate relevant articles. The function of isoflavones in multiple sclerosis is examined in this review, with particular attention paid to their mechanisms of action, which include immune response modulation, antioxidant effects, and possible influence on neurodegenerative processes. This review discusses the preclinical data that currently supports isoflavones' capacity to lower inflammation, enhance myelin repair, and slow the progression in MS models. Future research directions are proposed, highlighting the challenges and limitations in implementing these findings in clinical practice. Even though isoflavones are still being studied, their promising role in MS treatment highlights the need for more research to assess their potential as supplemental therapies in managing MS symptoms and progression.
髓鞘变性是多发性硬化症的一个标志，多发性硬化症是一种慢性自身免疫性神经疾病，会改变中枢神经系统的通信。尽管多发性硬化症的病理生理学是多因素的且尚未完全了解，但新的研究表明，减少氧化应激和炎症可能具有治疗优势。一类称为异黄酮的植物雌激素，主要存在于大豆和其他豆类中，因其可能具有的抗炎和神经保护特性而受到关注。利用PubMed、Scopus、ScienceDirect和谷歌学术等各种数据库，对2000年至2024年期间的文献进行了全面综述。这个过程涉及使用特定的搜索词和布尔运算符，包括“异黄酮”和“多发性硬化症”、“植物雌激素”和“神经保护”，以及“大豆异黄酮”和“自身免疫性疾病”，以查找相关文章。本综述研究了异黄酮在多发性硬化症中的作用，特别关注其作用机制，包括免疫反应调节、抗氧化作用以及对神经退行性过程的可能影响。本综述讨论了目前支持异黄酮降低炎症、增强髓鞘修复以及减缓多发性硬化症模型进展能力的临床前数据。提出了未来的研究方向，强调了在临床实践中应用这些发现所面临的挑战和局限性。尽管异黄酮仍在研究中，但它们在多发性硬化症治疗中的潜在作用凸显了需要更多研究来评估其作为辅助疗法管理多发性硬化症症状和进展的潜力。
