Ren Mian, Cao Luxi, Shen Quanquan, Zhu Bin, Wu Juan
Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Urology and Nephrology Center, Hangzhou Medical College, Hangzhou, China.
Front Med (Lausanne). 2025 Aug 15;12:1627010. doi: 10.3389/fmed.2025.1627010. eCollection 2025.
Mantle cell lymphoma (MCL) is a rare, aggressive non-Hodgkin lymphoma (NHL) that can affect the kidneys. In this research, we described a very rare case of secondary membranous nephropathy (MN) associated with MCL. A 67-year-old man manifested with impaired renal function and nephrotic syndrome (NS). Kidney biopsy revealed atypical MN and MCL cell infiltration. After eight rounds of modified R-CHOP therapy, which includes rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone, the patient achieved complete remission, accompanied by improved renal function and a reduction in proteinuria. This case demonstrates the precise diagnosis and treatment of the primary disease, which can lead to favorable outcomes.
套细胞淋巴瘤（MCL）是一种罕见的侵袭性非霍奇金淋巴瘤（NHL），可累及肾脏。在本研究中，我们描述了一例非常罕见的与MCL相关的继发性膜性肾病（MN）病例。一名67岁男性表现为肾功能损害和肾病综合征（NS）。肾脏活检显示非典型MN和MCL细胞浸润。经过八轮改良的R-CHOP治疗（包括利妥昔单抗、环磷酰胺、多柔比星、长春新碱和泼尼松龙），患者实现完全缓解，同时肾功能改善，蛋白尿减少。该病例证明了对原发性疾病的精确诊断和治疗可带来良好预后。
