Lu Meixu, Zhang Yan, Shi Leiming, Wang Qianlong, Yang Xiaohua, Ma Haitao, Wang Mingzhen, Zhao Yuping, Miao Qi
School of Mental Health, Jining Medical University, Jining, People's Republic of China.
Shandong Mental Health Center (Affiliated Mental Health Center of Shandong University), Shandong Provincial Key Medical and Health Discipline of Gerontology (Shandong Mental Health Center), Jinan, Shandong, People's Republic of China.
Neuropsychiatr Dis Treat. 2025 Aug 25;21:1751-1760. doi: 10.2147/NDT.S534235. eCollection 2025.
The aim of this study was to explore the relationship between whole blood cell-derived inflammatory markers and clinical symptoms in patients with late-life depression (LLD). It also aimed to explore the predictive value of whole blood cell-derived inflammatory markers on the efficacy of short-term medication.
Eighty-three patients with LLD were included, and their baseline demographics, routine blood test results and clinical characteristics before and after 2 weeks of treatment were collected. Whole-blood cell-derived inflammatory markers at pre-treatment were calculated. Additionally, correlation analysis was used to explore the correlation between inflammatory makers and clinical characteristics. Multivariable logistic regression was used to analyze the factors influencing short-term outcomes in patients. The predictive value of whole blood cell-derived inflammatory markers for short-term outcomes was evaluated by plotting receiver operating characteristic (ROC) curve.
In this study, baseline PLR showed a positive correlation with the patients' HAMA scores at baseline. Furthermore, the levels of NLR, MLR, and NPR at baseline were negatively correlated with the patients' percentage reduction in HAMD score after 2 weeks of treatment. Regression analysis showed that baseline NPR was an independent risk factor affecting the efficacy of short-term pharmacological treatment. ROC curve analysis showed that the area under the curve of baseline NPR for predicting the outcome of short-term treatment was 0.713.
There is a correlation between baseline whole blood cell-derived inflammatory markers and anxiety symptoms and short-term antidepressant efficacy in patients with LLD. Pre-treatment NPR levels may be an independent risk factor influencing the short-term treatment outcome in patients with LLD, and it may have a potential predictive value for short-term treatment efficacy.
本研究旨在探讨老年期抑郁症（LLD）患者全血细胞衍生炎症标志物与临床症状之间的关系。同时，本研究还旨在探讨全血细胞衍生炎症标志物对短期药物治疗疗效的预测价值。
纳入83例LLD患者，收集其基线人口统计学资料、血常规检查结果以及治疗2周前后的临床特征。计算治疗前全血细胞衍生炎症标志物水平。此外，采用相关性分析探讨炎症标志物与临床特征之间的相关性。采用多变量逻辑回归分析影响患者短期预后的因素。通过绘制受试者工作特征（ROC）曲线评估全血细胞衍生炎症标志物对短期预后的预测价值。
在本研究中，基线血小板与淋巴细胞比值（PLR）与患者基线汉密尔顿焦虑量表（HAMA）评分呈正相关。此外，基线中性粒细胞与淋巴细胞比值（NLR）、单核细胞与淋巴细胞比值（MLR）和中性粒细胞与血小板比值（NPR）水平与患者治疗2周后汉密尔顿抑郁量表（HAMD）评分的降低百分比呈负相关。回归分析显示，基线NPR是影响短期药物治疗疗效的独立危险因素。ROC曲线分析显示，基线NPR预测短期治疗结局的曲线下面积为0.713。
LLD患者基线全血细胞衍生炎症标志物与焦虑症状及短期抗抑郁疗效之间存在相关性。治疗前NPR水平可能是影响LLD患者短期治疗结局的独立危险因素，且可能对短期治疗疗效具有潜在预测价值。
