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电针足三里通过调节肠易激综合征大鼠的前扣带回-杏仁核基底外侧核环路减轻内脏高敏感性和焦虑

Electroacupuncture at ST36 Alleviates Visceral Hypersensitivity and Anxiety via ACC-AIC Circuit Modulation in IBS Rats.

作者信息

Wang Dan, Guo Yixuan, Wu Zhichun, Zhang Haiyan

机构信息

College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, People's Republic of China.

College of Acupuncture-Moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250355, People's Republic of China.

出版信息

Neuropsychiatr Dis Treat. 2025 Aug 25;21:1761-1781. doi: 10.2147/NDT.S535518. eCollection 2025.

DOI:10.2147/NDT.S535518
PMID:40893930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12396234/
Abstract

PURPOSE

This study aimed to explore the effects of Electroacupuncture (EA) at the Zusanli (ST36) point on Irritable Bowel Syndrome (IBS), along with its associated visceral hypersensitivity and anxiety-like behaviors.

METHODS

To establish the IBS rat model, Water Avoidance Stress (WAS) was used. After successful modeling, rats were randomly divided into four groups: Normal group, IBS group, ST36 group, and Sham EA group. The ST36 group received EA at bilateral ST36 acupoints, while the Sham EA group underwent identical procedures without electrical stimulation. Visceral hypersensitivity was assessed using abdominal withdrawal reflex (AWR) scores, and anxiety-like behaviors were evaluated through open field test and elevated plus maze. Neuronal activation was measured via c-Fos expression, and multi-channel electrophysiological recordings from the anterior cingulate cortex (ACC) and anterior insular cortex (AIC) regions were analyzed for neural activity patterns. Autonomic nervous function was assessed through heart rate variability analysis.

RESULTS

EA at ST36 acupoint effectively alleviated visceral hypersensitivity and anxiety-like behaviors in IBS rats. The treatment normalized abnormal neural activity and local field potential (LFP) oscillations in the ACC and AIC regions. Specifically, EA corrected the pathologically increased firing rates and irregular discharge patterns in both neuronal types within these brain regions. Furthermore, EA reduced the pathologically enhanced synchronization between ACC and AIC in delta (0.5-3 Hz) and theta (3-8 Hz) frequency bands. EA also ameliorated autonomic nervous dysfunction associated with IBS manifestations.

CONCLUSION

These findings indicate that EA at ST36 acupoint modulates neuronal activity in the ACC and AIC regions, thereby alleviating visceral hypersensitivity and anxiety-like behaviors in IBS rats, and improving autonomic nervous function.

摘要

目的

本研究旨在探讨电针足三里穴（ST36）对肠易激综合征（IBS）及其相关内脏高敏感性和焦虑样行为的影响。

方法

采用水回避应激（WAS）建立IBS大鼠模型。造模成功后，将大鼠随机分为四组：正常组、IBS组、ST36组和假电针组。ST36组在双侧ST36穴位接受电针治疗，而假电针组进行相同操作但无电刺激。使用腹部退缩反射（AWR）评分评估内脏高敏感性，并通过旷场试验和高架十字迷宫评估焦虑样行为。通过c-Fos表达测量神经元激活，并分析前扣带回皮质（ACC）和前岛叶皮质（AIC）区域的多通道电生理记录以观察神经活动模式。通过心率变异性分析评估自主神经功能。

结果

电针ST36穴位有效减轻了IBS大鼠的内脏高敏感性和焦虑样行为。该治疗使ACC和AIC区域的异常神经活动和局部场电位（LFP）振荡恢复正常。具体而言，电针纠正了这些脑区内两种神经元类型的病理性放电率增加和不规则放电模式。此外，电针降低了ACC和AIC在δ（0.5 - 3 Hz）和θ（3 - 8 Hz）频段病理性增强的同步性。电针还改善了与IBS表现相关的自主神经功能障碍。

结论

这些发现表明，电针ST36穴位可调节ACC和AIC区域的神经元活动，从而减轻IBS大鼠的内脏高敏感性和焦虑样行为，并改善自主神经功能。

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