通过孟德尔随机化分析和病例对照试验预测的子宫内膜异位症新治疗靶点。
New therapeutic targets for endometriosis predicted through mendelian randomization analysis and case-control trials.
作者信息
Zheng Linyao, Yin Yue, Wang Xiaotong, Wang Baoju, Cui Ran, Zhang Guangmei
机构信息
Department of Gynaecology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Obstertrics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
出版信息
Front Genet. 2025 Aug 15;16:1631446. doi: 10.3389/fgene.2025.1631446. eCollection 2025.
INTRODUCTION
Endometriosis is a common chronic gynecological condition that affects approximately 10% of women of reproductive age worldwide.
METHODS
This study utilized large-scale genome-wide association study data and explored the causal relationship between blood metabolites, plasma proteins, and endometriosis via Mendelian randomization and colocalization analysis methods. Clinical pathological data were collected, and hypotheses were validated through experiments such as ELISA, RT-qPCR, and Western blotting.
RESULTS
and were found to be potentially associated with endometriosis within the proteome. External validation and colocalization analysis confirmed the robustness of the association with . Blood and tissue samples were collected from clinical patients to assess the accuracy of these predictions.
DISCUSSION
These results suggest that may be a new target for the treatment of endometriosis, providing a direction for future drug development.
引言
子宫内膜异位症是一种常见的慢性妇科疾病，全球约10%的育龄妇女受其影响。
方法
本研究利用大规模全基因组关联研究数据，通过孟德尔随机化和共定位分析方法探索血液代谢物、血浆蛋白与子宫内膜异位症之间的因果关系。收集临床病理数据，并通过ELISA、RT-qPCR和蛋白质印迹等实验验证假设。
结果
在蛋白质组中发现 与子宫内膜异位症可能相关。外部验证和共定位分析证实了与 的关联的稳健性。从临床患者收集血液和组织样本以评估这些预测的准确性。
讨论
这些结果表明 可能是治疗子宫内膜异位症的新靶点，为未来药物开发提供了方向。
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