Mehdipour Aida, Hossein Nattaj Mojtaba, Fateh Roohollah, Aghaali Mohammad, Qomeisi Romina, Saleh Ali, Kalantar Neyestanaki Mohammad Hassan
Cellular and Molecular Research Center, Qom University of Medical sciences, Qom, Iran.
Dept. of Pediatric Dentistry, Dental Faculty, Qom University of Medical Sciences, Qom, Iran.
J Dent (Shiraz). 2025 Sep 1;26(3):210-219. doi: 10.30476/dentjods.2024.102462.2364. eCollection 2025 Sep.
Childhood obesity is an increasing global health concern associated with both systemic and oral complications. While studies suggest links between body mass index (BMI) and oral health markers, these relationships remain poorly defined.
This study evaluated the association between salivary microbial/fungal populations, salivary acidity, and obesity in children.
In this cross-sectional descriptive study (2021-2022), 90 children aged 8-12 from public schools in Qom, Iran, were categorized into three groups based on BMI: 30 children with normal weight, 30 overweight children, and 30 obese children. Demographic information, including parental education and occupation, was recorded. Unstimulated saliva samples were collected using the passive drooling method. A total of 0.5 ml of saliva was mixed with 5 ml of phosphate-buffered saline (PBS) and homogenized thoroughly by using a shaker. Microbiological analysis involved quantifying colonies of and and measuring salivary pH using a calibrated pH meter. Data were analyzed using appropriate statistical tests with significance set at < 0.05.
No significant relationship was found between childhood obesity and parental education (father's = 0.051, mother's = 0.862) or occupation (father's = 0.224, mother's = 0.893). Salivary pH did not differ significantly between weight groups (= 0.639). Overweight children had lower levels (= 0.857), and obese children had higher levels (= 0.777); though neither correlated significantly with BMI. colonies showed a significant negative correlation with childhood obesity (= 0.046). Significant associations were also observed between (= 0.046) and Lactobacillus (= 0.002) levels with levels.
Although oral bacterial levels did not differ significantly across weight groups, fungal species, particularly , varied significantly. A negative association between obesity and counts suggests that obesity may impact the salivary microbial ecosystem, highlighting the need for further research into its systemic and oral health implications.
儿童肥胖是一个日益引起全球关注的健康问题，与全身和口腔并发症相关。虽然研究表明体重指数（BMI）与口腔健康指标之间存在联系，但这些关系仍不明确。
本研究评估了儿童唾液微生物/真菌群落、唾液酸度与肥胖之间的关联。
在这项横断面描述性研究（2021 - 2022年）中，来自伊朗库姆公立学校的90名8 - 12岁儿童根据BMI分为三组：30名体重正常儿童、30名超重儿童和30名肥胖儿童。记录了包括父母教育程度和职业在内的人口统计学信息。使用被动流涎法收集非刺激性唾液样本。将总共0.5毫升唾液与5毫升磷酸盐缓冲盐水（PBS）混合，并使用振荡器充分匀浆。微生物分析包括对 和 的菌落进行定量，并使用校准的pH计测量唾液pH值。使用适当的统计检验对数据进行分析，显著性设定为<0.05。
未发现儿童肥胖与父母教育程度（父亲的 = 0.051，母亲的 = 0.862）或职业（父亲的 = 0.224，母亲的 = 0.893）之间存在显著关系。体重组之间的唾液pH值无显著差异（ = 0.639）。超重儿童的 水平较低（ = 0.857），肥胖儿童的 水平较高（ = 0.777）；尽管两者与BMI均无显著相关性。 菌落与儿童肥胖呈显著负相关（ = 0.046）。 （ = 0.046）和乳酸杆菌（ = 0.002）水平与 水平之间也观察到显著关联。
尽管不同体重组之间口腔细菌水平无显著差异，但真菌种类，尤其是 ，差异显著。肥胖与 计数之间的负相关表明肥胖可能影响唾液微生物生态系统，突出了对其全身和口腔健康影响进行进一步研究的必要性。
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