Cambier J, Masson M, Viader F, Limodin J, Strube A
Rev Neurol (Paris). 1985;141(8-9):528-36.
Neuropsychological findings in 10 clinical cases of progressive supranuclear palsy are presented. Patients were aged 52 to 80 and the duration of their illness was 1 to 5 years. Severe psychological disturbances e.g. depression or outbursts of irritability were prominent features in 5 patients. Formal neuropsychological testing disclosed mental slowing, impaired attention, reduced verbal fluency and elaborated linguistic abilities, poor abstract thinking and reasoning, mild to moderate memory loss, dynamic apraxia, grasping, motor impersistence, imitation and utilization behaviour. The clinical similarities between these neuropsychological changes and frontal lobe syndromes, together with the lack of cortical involvement, suggest that the "dementia" of progressive supranuclear palsy could be explained by deactivation of the frontal cortex by subcortical lesions. The special importance of pallidal and mesencephalic reticular involvement in the syndrome is hypothetized.
本文报告了10例进行性核上性麻痹临床病例的神经心理学研究结果。患者年龄在52岁至80岁之间，病程为1至5年。5例患者有严重的心理障碍，如抑郁或易怒发作等突出症状。正式的神经心理学测试显示，患者存在思维迟缓、注意力受损、语言流畅性降低、语言能力精细化受损、抽象思维和推理能力差、轻度至中度记忆丧失、动态失用症、抓握、运动持续性障碍、模仿和利用行为。这些神经心理学变化与额叶综合征在临床上的相似性，以及缺乏皮质受累，提示进行性核上性麻痹的“痴呆”可能是由皮质下病变导致额叶皮质失活所解释。推测苍白球和中脑网状结构受累在该综合征中具有特殊重要性。
