Jin Yiling, Bai Zhiming, Wang Gang, Zhang Yu, Chen Jing
Department of Radiology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, China.
Department of Urology, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, China.
Curr Urol. 2025 Sep;19(5):303-308. doi: 10.1097/CU9.0000000000000288. Epub 2025 May 23.
Spatial transcriptomics, an increasingly prominent technique, has been extensively utilized to examine tumors within the digestive tract (such as liver and colorectal cancers) and the nervous system. However, its application in prostate cancer research remains comparatively limited. This article provides a detailed overview of the principles and features of spatial transcriptomics, particularly highlighting its applications in studying the tumor microenvironment, heterogeneity, and clinical implications in prostate cancer. Through a systematic review and analysis of current literature, we identify the main focus areas and limitations of existing research on spatial transcriptomics and suggest potential future research directions.
空间转录组学是一种日益突出的技术，已被广泛用于研究消化道肿瘤（如肝癌和结直肠癌）以及神经系统。然而，其在前列腺癌研究中的应用仍然相对有限。本文详细概述了空间转录组学的原理和特点，特别强调了其在研究前列腺癌肿瘤微环境、异质性及临床意义方面的应用。通过对当前文献的系统综述和分析，我们确定了空间转录组学现有研究的主要重点领域和局限性，并提出了未来潜在的研究方向。
