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Effect of opioid sparing anesthesia with esketamine on PONV in laparoscopic sleeve gastrectomy randomized trial.

作者信息

Shi Kai-Rui, Zhao Min, Liu Ke, Yu Da-Peng, Zhang Bing-Yuan, Hong Hua, Jiang Lin, Yang Chun

机构信息

Department of Anesthesiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu 225300, China.

Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.

出版信息

iScience. 2025 Jul 31;28(9):113253. doi: 10.1016/j.isci.2025.113253. eCollection 2025 Sep 19.

DOI:10.1016/j.isci.2025.113253
PMID:40894866
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12392309/
Abstract

Postoperative nausea and vomiting (PONV) remains highly prevalent in laparoscopic sleeve gastrectomy (LSG), with intraoperative opioid use being a key contributing factor. We conducted a prospective, double-blind, randomized trial to compare esketamine-based opioid-sparing anesthesia (OSA) to opioid-based anesthesia in adults undergoing LSG, The primary outcome was the incidence of PONV within 48 h postoperatively. OSA was associated with a significant reduction in the overall incidence of PONV within 48 h, while maintaining comparable analgesic efficacy or postoperative recovery. Additionally, OSA showed clinically significant reductions in both PONV incidence within the first 24 h and severity specifically during the 6-24-h period. Results suggest that OSA is an effective strategy for mitigating PONV following LSG.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f67/12392309/5a50158ebf82/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f67/12392309/b913a2636263/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f67/12392309/a75879f9e7a5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f67/12392309/5a50158ebf82/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f67/12392309/b913a2636263/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f67/12392309/a75879f9e7a5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f67/12392309/5a50158ebf82/gr2.jpg

相似文献

[1]
Effect of opioid sparing anesthesia with esketamine on PONV in laparoscopic sleeve gastrectomy randomized trial.

iScience. 2025-7-31

[2]
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[3]
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Front Med (Lausanne). 2025-7-17

[4]
Effect of Opioid-Free Versus Opioid Anesthesia on the Quality of Postoperative Recovery in Patients Receiving Laparoscopic Sleeve Gastrectomy.

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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
GLP-1 receptor agonists and the risk of postoperative nausea and vomiting after laparoscopic sleeve gastrectomy: a single-center, retrospective cohort study.

Surg Obes Relat Dis. 2025-3

本文引用的文献

[1]
The effect of laparoscopic vertical sleeve gastrectomy and laparoscopic roux-en-Y gastric bypass on gastroesophageal reflux disease: An updated meta-analysis and systematic review of 5-year post-operative data from randomized controlled trials.

Surg Endosc. 2024-11

[2]
The impact of perioperative ketamine or esketamine on the subjective quality of recovery after surgery: a meta-analysis of randomised controlled trials.

Br J Anaesth. 2024-6

[3]
Opioid-Sparing Anesthesia Versus Opioid-Free Anesthesia for the Prevention of Postoperative Nausea and Vomiting after Laparoscopic Bariatric Surgery: A Systematic Review and Network Meta-Analysis.

Anesth Analg. 2025-2-1

[4]
Long term outcomes of metabolic/bariatric surgery in adults.

BMJ. 2023-12-18

[5]
Opioid-free versus opioid-sparing anaesthesia in ambulatory total hip arthroplasty: a randomised controlled trial.

Br J Anaesth. 2024-2

[6]
Opioid-free anaesthesia reduces postoperative nausea and vomiting after thoracoscopic lung resection: a randomised controlled trial.

Br J Anaesth. 2024-2

[7]
Anesthesia for Morbidly Obese Patients.

Dtsch Arztebl Int. 2023-11-17

[8]
Intraoperative Sufentanil Consumption and the Risk of Postoperative Nausea and/or Vomiting: A Retrospective Observational Study.

Pain Ther. 2023-10

[9]
Opioid-free anesthesia: A systematic review and meta-analysis.

J Clin Anesth. 2023-11

[10]
Intraoperative Esketamine Is Effective at Reducing Acute Postoperative Pain in Bariatric Surgery Patients: a Randomized Control Trial.

Obes Surg. 2023-8

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