Chen Xier, Yuan Yingge, Zhou Xuchang, Deng Huili, Zhang Jun, Duan Shuning, Ni Guoxin
School of Sports Medicine, Wuhan Sports University, Wuhan 430079, China.
Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361003, China.
iScience. 2025 Aug 5;28(9):113257. doi: 10.1016/j.isci.2025.113257. eCollection 2025 Sep 19.
Bone metabolism is a dynamic process involving remodeling and rebuilding bone tissue. Important participants in this process include osteoblasts and osteoclasts, which may promote bone formation and bone resorption, respectively. Cumulative evidence suggests that taurine, a sulfur-containing nonessential amino acid, can regulate bone formation, bone resorption, and bone immunity through anti-inflammatory and antioxidant properties in bone metabolic diseases. However, the potential mechanisms by which taurine regulates bone metabolism remain unclear. This review focuses on the potential role of taurine in bone metabolic diseases, particularly osteoporosis and rheumatoid arthritis. Moreover, the regulatory mechanisms of taurine on bone formation, bone resorption, and bone immunity are summarized, which provides a theoretical basis for the application of taurine as a therapeutic agent to improve bone metabolic diseases.
骨代谢是一个涉及骨组织重塑和重建的动态过程。这一过程的重要参与者包括成骨细胞和破骨细胞，它们分别可能促进骨形成和骨吸收。越来越多的证据表明，牛磺酸作为一种含硫的非必需氨基酸，可通过在骨代谢疾病中的抗炎和抗氧化特性来调节骨形成、骨吸收和骨免疫。然而，牛磺酸调节骨代谢的潜在机制仍不清楚。本综述重点关注牛磺酸在骨代谢疾病，特别是骨质疏松症和类风湿性关节炎中的潜在作用。此外，总结了牛磺酸对骨形成、骨吸收和骨免疫的调节机制，为牛磺酸作为治疗药物改善骨代谢疾病的应用提供了理论依据。
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