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Identification of plasma lipid metabolism and potential biomarkers in patients with different coronary occlusive acute myocardial infarction.

作者信息

Chen Hao, Zhang Qingyi, Zhou Ai, Zhang Li, Li Xing

机构信息

Department of Cardiology, Wuxi No. 2 People's Hospital of Jiangnan University Medical Center, Wuxi, Jiangsu, China.

Department of Cardiology, Affiliated Changzhou Children's Hospital of Nantong University, Changzhou, China.

出版信息

Front Cell Dev Biol. 2025 Aug 14;13:1575431. doi: 10.3389/fcell.2025.1575431. eCollection 2025.

DOI:10.3389/fcell.2025.1575431
PMID:40894931
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12391077/
Abstract

Acute myocardial infarction (AMI) is the main cause of death worldwide. We aim to compare the differences in plasma lipid metabolites between AMI patients and normal controls to search for biomarker molecules for AMI with different infarct sites. We enrolled 12 patients in Group A (left coronary artery occlusion), 15 in Group B (right coronary artery occlusion), and 14 in Group C (normal controls) from June 2020 to June 2021. Non-targeted lipidomic analysis was performed and a total of 93 differential lipid molecules were identified. Diagnostic efficiency was evaluated by receiver operating curve. Compared with Group C, there were nine lipid molecules with AUC>0.8 in Groups A and B. Compared with Group B, Group A had six lipid molecules with AUC>0.8. These lipid molecules belonged to the LPC, PC, TG, and DG classes. We focused on LPC (20:4) as a biomarker in AMI.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/979f381d2b0a/fcell-13-1575431-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/ef46d4fa1dec/fcell-13-1575431-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/50beb71a87f3/fcell-13-1575431-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/a534b72f7e31/fcell-13-1575431-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/49ec8e426909/fcell-13-1575431-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/e8a6d3c6e076/fcell-13-1575431-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/de09cd0a0a52/fcell-13-1575431-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/2ee6c3cd0418/fcell-13-1575431-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/4b9e73cd9d09/fcell-13-1575431-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/6cc84b2dfb2e/fcell-13-1575431-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/979f381d2b0a/fcell-13-1575431-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/ef46d4fa1dec/fcell-13-1575431-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/50beb71a87f3/fcell-13-1575431-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/a534b72f7e31/fcell-13-1575431-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/49ec8e426909/fcell-13-1575431-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/e8a6d3c6e076/fcell-13-1575431-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/de09cd0a0a52/fcell-13-1575431-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/2ee6c3cd0418/fcell-13-1575431-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/4b9e73cd9d09/fcell-13-1575431-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/6cc84b2dfb2e/fcell-13-1575431-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/329e/12391077/979f381d2b0a/fcell-13-1575431-g010.jpg

相似文献

[1]
Identification of plasma lipid metabolism and potential biomarkers in patients with different coronary occlusive acute myocardial infarction.

Front Cell Dev Biol. 2025-8-14

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[8]
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[9]
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[10]
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本文引用的文献

[1]
B-type natriuretic peptide and cardiac remodelling after myocardial infarction: a randomised trial.

Heart. 2021-3

[2]
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China.

J Cell Mol Med. 2020-2

[3]
Linking regulation of nitric oxide to endothelin-1: The Yin and Yang of vascular tone in the atherosclerotic plaque.

Atherosclerosis. 2020-1

[4]
Ceramide subclasses identified as novel lipid biomarker elevated in women with polycystic ovary syndrome: a pilot study employing shotgun lipidomics.

Gynecol Endocrinol. 2020-6

[5]
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

Circulation. 2019-9-10

[6]
Lipidomics of Bioactive Lipids in Acute Coronary Syndromes.

Int J Mol Sci. 2019-2-28

[7]
Low plasma lysophosphatidylcholines are associated with impaired mitochondrial oxidative capacity in adults in the Baltimore Longitudinal Study of Aging.

Aging Cell. 2019-2-4

[8]
Metabolic profiling identifies phospholipids as potential serum biomarkers for schizophrenia.

Psychiatry Res. 2018-12-7

[9]
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.

Lancet. 2018-11-8

[10]
Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients.

J Lipid Res. 2018-6-1

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