用于活细胞成像和CFTR活性评估的选择性碘化物指示剂的开发。
Development of a selective-iodide indicator for live-cell imaging and evaluation of CFTR activity.
作者信息
Morse Jared, Ganesh Prasanna, Cowart Kathrine, Ballestas Gabriella, Tang Fung Kit, Leung Kaho
机构信息
Department of Chemistry & Biochemistry, Clarkson University NY 13676 USA.
Department of Chemistry & Biochemistry, University of South Carolina Columbia SC 29208 USA
出版信息
Sens Diagn. 2025 Aug 28. doi: 10.1039/d5sd00086f.
Cystic fibrosis (CF) arises from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Monitoring I transport serves as a critical approach for evaluating CFTR function in live cells, providing a foundation for the development of diagnostic tools and therapeutic treatments. Here, we report an iridium(iii) complex () for the selective and pH-independent imaging of intracellular I. By tracking cellular iodide I uptake, facilitates the evaluation of CFTR activity in live cells, providing a valuable tool for the functional characterization of CFTR activity.
囊性纤维化（CF）由囊性纤维化跨膜传导调节因子（CFTR）基因突变引起。监测碘转运是评估活细胞中CFTR功能的关键方法，为诊断工具和治疗方法的开发奠定了基础。在此，我们报告了一种铱（III）配合物（），用于细胞内碘的选择性和pH无关成像。通过追踪细胞对碘离子的摄取，有助于评估活细胞中的CFTR活性，为CFTR活性的功能表征提供了一种有价值的工具。
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