Kokudo Takashi, Halkic Nermin, Kokudo Norihiro
National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo, Japan.
Clinique Cecil, Lausanne, Switzerland.
Glob Health Med. 2025 Aug 31;7(4):275-278. doi: 10.35772/ghm.2025.01088.
Liver resection (LR) remains a cornerstone curative option for patients with hepatocellular carcinoma (HCC), and yet the high rate of postoperative intrahepatic recurrence poses a significant clinical challenge. Despite numerous attempts, no adjuvant therapy has shown definitive efficacy in preventing recurrence. In this context, salvage liver transplantation (SLT) and repeat hepatectomy (RH) have emerged as key curative strategies for recurrent disease. While SLT is associated with the most favorable survival outcomes, limited donor availability, particularly in Eastern countries, often necessitates the use of RH, which can also offer promising results. These evolving treatment strategies underscore the urgent need for improved risk stratification, optimized surgical decision-making, and innovative approaches to managing recurrent HCC.
肝切除术(LR)仍然是肝细胞癌(HCC)患者的一种关键治愈性选择,然而术后肝内复发率高构成了重大的临床挑战。尽管进行了无数尝试,但尚无辅助治疗在预防复发方面显示出确切疗效。在此背景下,挽救性肝移植(SLT)和再次肝切除术(RH)已成为复发性疾病的关键治愈策略。虽然SLT与最有利的生存结果相关,但供体可用性有限,尤其是在东方国家,这常常使得有必要采用RH,RH也能带来有希望的结果。这些不断发展的治疗策略凸显了改善风险分层、优化手术决策以及创新复发性HCC管理方法的迫切需求。