Cai Tengteng
Department of Radiotherapy, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai 200434, P.R. China.
Oncol Lett. 2025 Aug 19;30(4):488. doi: 10.3892/ol.2025.15234. eCollection 2025 Oct.
Nasopharyngeal carcinoma (NPC) is a common head and neck malignancy, particularly in southern China, with distant metastasis posing significant treatment challenges, particularly in elderly patients. This case report details the successful management of a 90-year-old male with NPC and lung metastasis. The patient underwent intensity-modulated radiotherapy for the nasopharyngeal tumor (70 Gy/35 fractions) with concurrent oral capecitabine, followed by stereotactic body radiotherapy (60 Gy/12 fractions) and immunotherapy (tislelizumab) for progressive lung lesions. Maintenance therapy with capecitabine was continued and the patient achieved stable disease with minimal adverse effects. This case highlights the efficacy of individualized multimodal therapy, including precision radiotherapy, chemotherapy and immunotherapy, in an elderly patient with NPC with metastasis, offering a potential framework for similar cases.
鼻咽癌（NPC）是一种常见的头颈部恶性肿瘤，在中国南方尤为常见，远处转移带来了重大的治疗挑战，尤其是在老年患者中。本病例报告详细介绍了一名90岁男性鼻咽癌伴肺转移患者的成功治疗过程。该患者接受了针对鼻咽肿瘤的调强放疗（70 Gy/35次分割），同时口服卡培他滨，随后对进展性肺部病变进行了立体定向体部放疗（60 Gy/12次分割）和免疫治疗（替雷利珠单抗）。继续使用卡培他滨进行维持治疗，患者病情稳定，不良反应轻微。本病例突出了个体化多模式治疗的疗效，包括精准放疗、化疗和免疫治疗，为一名老年转移性鼻咽癌患者提供了潜在的治疗框架，也为类似病例提供了参考。
