Niu Pengfei, Guo Rong, Ding Chan, Yu Shengqing
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), Shanghai, 200241, PR China.
Jiangsu Agri-Animal Husbandry Vocational College, Veterinary Bio-Pharmaceutical, Jiangsu Key Laboratory for High-Tech Research and Development of Veterinary Biopharmaceuticals, Taizhou, 225309, PR China.
Curr Res Microb Sci. 2025 May 12;9:100404. doi: 10.1016/j.crmicr.2025.100404. eCollection 2025.
The type IX secretion system (T9SS) is specific to the Fibrobacteres-Chlorobi-Bacteroidetes superphylum, the members of which have many specialized features, including gliding motility and the transport of cargo proteins across the outer membrane. At least 20 proteins have been identified as the components of T9SS. Proteins secreted by T9SS use the Sec system to cross the inner membrane, and the conserved C-terminal domain targets them to the T9SS for delivery to the extracellular environment or attachment to the outer membrane. is an important pathogen of waterfowl, causing septicemic and exudative diseases. A genetic analysis recently detected T9SS in , in which it transports proteins and affects virulence. Moreover, at least 19 T9SS-transported proteins in strain Yb2 were identified, with multiple functions and affecting in different ways. In this review, we focus on recent advances in our understanding of the structure, function, and organization of the T9SS machinery and new findings about this highly novel secretion system in .
IX型分泌系统（T9SS）特定存在于纤维杆菌-绿菌-拟杆菌超门中，该超门的成员具有许多特殊特征，包括滑行运动以及货物蛋白跨外膜运输。至少20种蛋白质已被鉴定为T9SS的组成成分。T9SS分泌的蛋白质利用Sec系统穿过内膜，保守的C末端结构域将它们靶向T9SS，以便递送到细胞外环境或附着在外膜上。[病原体名称]是水禽的重要病原体，可引起败血性和渗出性疾病。最近的一项遗传分析在[病原体名称]中检测到T9SS，它在其中运输蛋白质并影响毒力。此外，在[病原体名称]菌株Yb2中鉴定出至少19种由T9SS运输的蛋白质，它们具有多种功能并以不同方式影响[病原体名称]。在本综述中，我们重点关注对T9SS机制的结构、功能和组织的最新认识进展以及关于[病原体名称]中这种高度新颖的分泌系统的新发现。
