Yokotani Yusaku, Kitae Hiroaki, Mazaki Mika
Department of Gastroenterology, Omihachiman Community Medical Center, Omihachiman, JPN.
Department of Gastroenterology, Asahi University Hospital, Gifu, JPN.
Cureus. 2025 Jul 28;17(7):e88876. doi: 10.7759/cureus.88876. eCollection 2025 Jul.
Cronkhite-Canada syndrome (CCS) is a rare, non-hereditary disease characterized by specific symptoms, ectodermal abnormalities, endoscopic findings, and pathological examination. We report a unique case of a 39-year-old man with suspicious CCS. Although the blood test showed iron-deficiency anemia and hypoalbuminemia, he exhibited no symptoms, including those related to CCS itself and anemia and hypoalbuminemia. According to the result of endoscopic and pathological examination, he was diagnosed with possible CCS. While following the patient's medical course, the serum albumin level gradually declined. Six months after the diagnosis, oral corticosteroid therapy was initiated to prevent disease progression. Consequently, the patient achieved a favorable clinical course without developing any symptoms. This case highlights the importance of considering CCS even in the absence of typical symptoms and suggests that therapeutic intervention may be beneficial even in asymptomatic presentations.
克朗凯特-加拿大综合征（CCS）是一种罕见的非遗传性疾病，其特征为特定症状、外胚层异常、内镜检查结果及病理检查。我们报告一例39岁男性疑似CCS的独特病例。尽管血液检查显示缺铁性贫血和低白蛋白血症，但他没有表现出任何症状，包括与CCS本身以及贫血和低白蛋白血症相关的症状。根据内镜和病理检查结果，他被诊断为可能患有CCS。在跟踪患者的病程时，血清白蛋白水平逐渐下降。诊断后6个月，开始口服糖皮质激素治疗以防止疾病进展。结果，患者临床病程良好，未出现任何症状。该病例强调了即使没有典型症状也需考虑CCS的重要性，并表明即使在无症状表现时进行治疗干预也可能有益。
