Wester P W, van der Heijden C A, Bisschop A, van Esch G J, Wegman R C, de Vries T
Sci Total Environ. 1985 Dec;47:427-32. doi: 10.1016/0048-9697(85)90347-x.
A lifetime carcinogenicity study was carried out in Wistar rats, with a mixture of the following halogenated hydrocarbons: trichloromethane, tetrachloromethane, monobromodichloromethane, trichloroethylene, tetrachloroethylene, 1,2-dichlorobenzene, 1,3,-dichlorobenzene, 1,4,-dichlorobenzene, 1,2,3,-trichlorobenzene, 1,2,4,-trichlorobenzene, 1,3,5-trichlorobenzene. From this mixture 0.22, 2.2, or 22 mg was added per liter drinking water representing concentrations being three orders of magnitude higher than found in several water wells. Most of the changes found in body weight, hematology and pathology correlated with intercurrent diseases or were in accordance with background pathology. With respect to incidence and time of occurrence of tumors, no significant differences were found between the control and the high dose group when lifespan correction was applied. Thus it is concluded that in the present study no significant toxic or carcinogenic effects are induced by lifetime exposure of rats to a mixture of volatile halogenated hydrocarbons in the drinking water.
在Wistar大鼠中进行了一项终生致癌性研究，使用的是以下卤代烃的混合物：三氯甲烷、四氯化碳、一溴二氯甲烷、三氯乙烯、四氯乙烯、1,2 - 二氯苯、1,3 - 二氯苯、1,4 - 二氯苯、1,2,3 - 三氯苯、1,2,4 - 三氯苯、1,3,5 - 三氯苯。在每升饮用水中添加0.22毫克、2.2毫克或22毫克的该混合物，这些浓度比在几口水井中发现的浓度高出三个数量级。在体重、血液学和病理学方面发现的大多数变化与并发疾病相关，或与背景病理学一致。在应用寿命校正后，对照组和高剂量组在肿瘤发生率和发生时间方面未发现显著差异。因此得出结论，在本研究中，大鼠终生饮用含有挥发性卤代烃混合物的水不会诱导显著的毒性或致癌作用。
