Esfandiarei Mitra, Anwar Faizan, Nuthi Manogna, Harrison Alisha, Barrameda Mary Eunice, Curry-Koski Tala, Pull Kasey, Currier Thomas Theresa, Jadavji Nafisa
Biomedical Sciences, Midwestern University, Downers Grove, Illinois, United States.
Department of Basic Medical Sciences, University of Arizona, Tucson, Arizona, United States.
MicroPubl Biol. 2025 Aug 14;2025. doi: 10.17912/micropub.biology.001651. eCollection 2025.
Marfan Syndrome (MFS) is an autosomal dominant genetic disorder that affects connective tissue throughout the body due to mutations in the fibrillin-1 ( gene. There is a gap in our understanding of the impact of monogenic connective tissue aberrations on the brain. This study aimed to determine the impact of MFS on neurodegeneration in the cortical brain tissue of mice. We report increased levels of apoptosis in neurons within the sensory and motor cortical areas of female MFS mice. Additionally, we also report increased levels of neuronal plasticity in cortical brain tissue of both male and female MFS mice.
马凡综合征（MFS）是一种常染色体显性遗传病，由于原纤维蛋白-1基因发生突变，影响全身的结缔组织。我们对单基因结缔组织畸变对大脑的影响了解不足。本研究旨在确定马凡综合征对小鼠大脑皮质组织神经退行性变的影响。我们报告称，雌性马凡综合征小鼠感觉和运动皮质区域的神经元凋亡水平增加。此外，我们还报告称，雄性和雌性马凡综合征小鼠大脑皮质组织中的神经元可塑性水平均有所增加。
